Ohno H, Kuraishi Y, Minami M, Satoh M
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Brain Res. 1988 Nov 22;474(1):197-200. doi: 10.1016/0006-8993(88)90685-3.
An intrathecal injection of antiserum against somatostatin significantly inhibited the nociceptive response to thermal but not mechanical stimulation in non-arthritic and adjuvant arthritic rats. The thermal antinociception induced by intrathecally injected anti-somatostatin antiserum was more remarkable in adjuvant arthritic rats than in non-arthritic ones. These results suggest that endogenous somatostatin participates in transmission of thermal nociception in the rat spinal dorsal horn in non-arthritic and arthritic conditions.
鞘内注射抗生长抑素抗血清可显著抑制非关节炎和佐剂性关节炎大鼠对热刺激而非机械刺激的伤害性反应。鞘内注射抗生长抑素抗血清诱导的热镇痛作用在佐剂性关节炎大鼠中比在非关节炎大鼠中更显著。这些结果表明，内源性生长抑素在非关节炎和关节炎状态下参与大鼠脊髓背角的热伤害性感受传递。
