Chiew Seet Khing, Ramasamy Thamil Selvee, Amini Farahnaz
Faculty of Medicine and Health Science, School of Healthy Aging, Medical Aesthetics and Regenerative Medicine, UCSI University, Kuala Lumpur, Malaysia.
Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
J Res Med Sci. 2016 Jun 14;21:38. doi: 10.4103/1735-1995.183988. eCollection 2016.
Plantar fasciitis (PF) is a common foot complaint, affects both active sportsmen and physically inactive middle age group. It is believed that PF results from degenerative changes rather than inflammation. Platelet-rich plasma (PRP) therapy has been introduced as an alternative therapy for PF. This study is aimed to systematically review to the effectiveness and relevant factors of PRP treatment in managing PF.
A search was conducted in electronic databases, including PubMed, Scopus, and Google Scholar using different keywords. Publications in English-language from 2010 to 2015 were included. Two reviewers extracted data from selected articles after the quality assessment was done.
A total of 1126 articles were retrieved, but only 12 articles met inclusion and exclusion criteria. With a total of 455 patients, a number of potentially influencing factors on the effectiveness of PRP for PF was identified. In all these studies, PRP had been injected directly into the plantar fascia, with or without ultrasound guidance. Steps from preparation to injection were found equally crucial. Amount of collected blood, types of blood anti-coagulant, methods in preparing PRP, speed, and numbers of time the blood samples were centrifuged, activating agent added to the PRP and techniques of injection, were varied between different studies. Regardless of these variations, superiority of PRP treatment compared to steroid was reported in all studies.
In conclusion, PRP therapy might provide an effective alternative to conservative management of PF with no obvious side effect or complication. The onset of action after PRP injection also greatly depended on the degree of degeneration.
足底筋膜炎（PF）是一种常见的足部疾病，影响着活跃的运动员和缺乏运动的中年人群体。人们认为足底筋膜炎是由退行性改变而非炎症引起的。富血小板血浆（PRP）疗法已被引入作为治疗足底筋膜炎的替代疗法。本研究旨在系统评价PRP治疗足底筋膜炎的有效性及相关因素。
使用不同关键词在电子数据库中进行检索，包括PubMed、Scopus和谷歌学术。纳入2010年至2015年发表的英文文献。两名评审员在完成质量评估后从选定的文章中提取数据。
共检索到1126篇文章，但只有12篇符合纳入和排除标准。共有455例患者，确定了一些可能影响PRP治疗足底筋膜炎有效性的因素。在所有这些研究中，PRP均直接注射到足底筋膜，有或没有超声引导。发现从制备到注射的步骤同样关键。不同研究之间，采集的血液量、血液抗凝剂类型、PRP制备方法、血液样本离心速度和次数、添加到PRP中的激活剂以及注射技术各不相同。尽管存在这些差异，但所有研究均报告PRP治疗优于类固醇治疗。
总之，PRP疗法可能为足底筋膜炎的保守治疗提供一种有效的替代方法，且无明显副作用或并发症。PRP注射后的起效时间也很大程度上取决于退变程度。
