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用于体内过亚硝酸根比率成像的可激活光声纳米探针。

Activatable Photoacoustic Nanoprobes for In Vivo Ratiometric Imaging of Peroxynitrite.

机构信息

School of Chemical and Biomedical Engineering, Nanyang Technological University, 637457, Singapore.

出版信息

Adv Mater. 2017 Feb;29(6). doi: 10.1002/adma.201604764. Epub 2016 Dec 1.

DOI:10.1002/adma.201604764
PMID:27906478
Abstract

Organic semiconducting nanoprobes doped with bulky borane can undergo specific activation by ONOO even at tumor-relevant acidic pH (6.8), permitting in vivo ratiometric photoacoustic imaging of ONOO in the tumor environment of living mice.

摘要

用大体积硼烷掺杂的有机半导体纳米探针甚至可以在与肿瘤相关的酸性 pH 值（6.8）下被 ONOO 特异性激活，从而允许在活体小鼠的肿瘤环境中进行 ONOO 的体内比率式光声成像。

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