胃癌患者脾脏淋巴细胞和巨噬细胞亚群的免疫组织化学评估

Immunohistochemical assessment of splenic lymphocyte and macrophage subpopulations in patients with gastric cancer.

作者信息

Falk S, Seipelt G, Müller H, Stutte H J

机构信息

Department of Pathology, University of Frankfurt, West Germany.

出版信息

Cancer. 1989 Oct 15;64(8):1646-51. doi: 10.1002/1097-0142(19891015)64:8<1646::aid-cncr2820640815>3.0.co;2-e.

DOI:10.1002/1097-0142(19891015)64:8<1646::aid-cncr2820640815>3.0.co;2-e

PMID:2790677

Abstract

In order to assess the effects of malignant tumors on the immune system, 25 spleens from patients with gastric carcinoma were studied by in situ immunohistochemical methods for lymphocyte subsets and cells of the mononuclear phagocyte system. Highly significant reductions of CD4+ T cells (P less than 0.001), Ki M2+ and Ki M-3+ MPS cells (P less than 0.02 and P less than 0.05), and a stage-dependent reduction of Ki 67+ B cell proliferation activity (P less than 0.05) were seen in spleens of patients with gastric cancer. These results, which were obtained by morphologic methods in a noninvolved lymphatic organ, reflect the systemic immunosuppressive and immunodepleting effects of malignant tumors that are probably mediated by tumor-associated cytokines.

摘要

为了评估恶性肿瘤对免疫系统的影响，采用原位免疫组化方法对25例胃癌患者的脾脏进行淋巴细胞亚群和单核吞噬细胞系统细胞研究。结果显示，胃癌患者脾脏中CD4+ T细胞显著减少（P<0.001），Ki M2+和Ki M-3+ MPS细胞显著减少（P<0.02和P<0.05），且Ki 67+ B细胞增殖活性呈分期依赖性降低（P<0.05）。这些通过形态学方法在未受累淋巴器官中获得的结果，反映了恶性肿瘤可能由肿瘤相关细胞因子介导的全身免疫抑制和免疫耗竭作用。