A complex t(3;8;17) involving breakpoint 8p11 in a case of M5 acute nonlymphocytic leukemia with erythrophagocytosis.
作者信息
Bertheas M F, Jaubert J, Vasselon C, Reynaud J, Pomier G, Le Petit J C, Hagemeijer A, Brizard C P
机构信息
Departement d'Hématologie, Immunologie et Cytogénétique, Centre Hospitalier et Universitaire de Saint-Etienne, France.
出版信息
Cancer Genet Cytogenet. 1989 Oct 1;42(1):67-73. doi: 10.1016/0165-4608(89)90009-5.
The t(8;16)(p11;p13) is a recently described new chromosome rearrangement of acute nonlymphocytic leukemia (ANLL). It appears to be specifically associated with acute monoblastic (AML-M5) or unusual myelomonocytic leukemia with prominent erythrophagocytosis in the leukemic cells. A complex t(3;8;17)(q27;p11;q12) is reported in a case of acute monoblastic leukemia with erythrophagocytosis. Sixteen cases of this t(8;16) and two other variant translocations are reviewed. The pathogenetic mechanism of the variant translocations is discussed, suggesting that the der(8) is a consistent recombinant.
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