Najfeld V, Scalise A, Troy K
Polly Annenberg Levee Hematology Center, Mount Sinai Medical Center, New York, NY 10029.
Cancer Genet Cytogenet. 1989 Nov;43(1):103-8. doi: 10.1016/0165-4608(89)90133-7.
Bone marrow cells from the majority of patients with acute promyelocytic leukemia (APL) are characterized by t(15;17)(q22;q11-12). At least 12 variant translocations have both also reported, and in each case, either abnormal chromosome 15 or del(17q) or both were involved in complex rearrangements. We report a patient with APL showing two translocations without apparent involvement of chromosome 15 and without del(17q). The karyotype was 46,XY,t(7;12)(p15;p13),t(11;17)(q13;q12). Rearrangement involving t(11;17) is probably associated with APL, while t(7;12) appears to be therapy related.
