Osella P, Wyandt H, Vosburgh E, Milunsky A
Center for Human Genetics, Boston University, Massachusetts.
Cancer Genet Cytogenet. 1991 Dec;57(2):201-7. doi: 10.1016/0165-4608(91)90153-l.
Chromosome analysis of bone marrow aspirate from a 46-year-old man with acute promyelocytic leukemia (APL) revealed a variant translocation, 46,XY,t(1:15;17)(p36;q22;q21.1). The breakpoints in chromosomes 15 and 17 appear to be the same as those in the more common translocation, t(15;17), associated with APL. The common translocation has been reported in up to 80% of cases of APL. Seventeen cases with variant translocations have been reported involving 15 alone, 17 alone, or 15, 17, and some other chromosome.
对一名46岁急性早幼粒细胞白血病（APL）男性患者的骨髓穿刺液进行染色体分析，发现一种变异易位，核型为46,XY,t(1:15;17)(p36;q22;q21.1)。15号和17号染色体上的断点似乎与更常见的与APL相关的易位t(15;17)中的断点相同。据报道，高达80%的APL病例存在这种常见易位。已有17例变异易位的报道，分别涉及单独的15号染色体、单独的17号染色体，或15号、17号染色体以及其他一些染色体。
