核酸感应Toll样受体：运输与调控
Nucleic acid-sensing TLRs: trafficking and regulation.
作者信息
Majer Olivia, Liu Bo, Barton Gregory M
机构信息
Division of Immunology & Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, United States.
出版信息
Curr Opin Immunol. 2017 Feb;44:26-33. doi: 10.1016/j.coi.2016.10.003. Epub 2016 Nov 28.
Abstract
Toll-like receptors (TLRs) play an important role in innate immune responses against pathogenic microorganisms or tissue damage. Nucleic acid (NA)-sensing TLRs localize in intracellular vesicular compartments and recognize foreign-derived and host-derived nucleic acid ligands. Inappropriate activation of NA-sensing TLRs can cause pathogenic inflammation and autoimmunity. Multiple regulatory mechanisms exist to limit recognition of self-NAs. This review summarizes recent progress that has been made in understanding how NA-sensing TLRs are regulated via trafficking, proteolytic cleavage, as well as ligand processing and recognition.
摘要
Toll样受体（TLRs）在针对病原微生物或组织损伤的固有免疫反应中发挥重要作用。核酸（NA）感应性TLRs定位于细胞内囊泡区室，并识别外源和宿主来源的核酸配体。NA感应性TLRs的不适当激活可导致致病性炎症和自身免疫。存在多种调节机制来限制对自身核酸的识别。本综述总结了在理解NA感应性TLRs如何通过运输、蛋白水解切割以及配体加工和识别进行调节方面所取得的最新进展。
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