一个近乎单倍体的克隆：来自一名处于慢性髓性白血病急变期患者的24,XY, t(9; 22)(q34; q11) 。
A near haploid clone: 24,XY, t (9; 22) (q34; q11) from a patient in blast crisis of chronic myeloid leukaemia.
作者信息
Daniel A, Francis S E, Stewart L A, Barber S
出版信息
Scand J Haematol. 1978 Aug;21(2):99-103. doi: 10.1111/j.1600-0609.1978.tb02499.x.
Abstract
Chromosome studies on bone marrow in a patient with chronic myeloid leukaemia (CML) revealed a mosaic picture with a dominant clone of 24,XY, t(9; 22) (q34; q11). This corresponded to a preponderance of minute blasts in smears of bone marrow aspirate. It is suggested that a haploidy event rather than progressive hypodiploid loss, is responsible for the genesis of the miniature blast cells.
摘要
对一名慢性粒细胞白血病（CML）患者的骨髓进行染色体研究，发现呈现嵌合现象，主要克隆为24,XY, t(9; 22) (q34; q11)。这与骨髓穿刺涂片中小原始细胞占优势相符。有人提出，单倍体事件而非渐进性亚二倍体丢失，是微型原始细胞产生的原因。
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