Murphy Charlotte, Rueschemeyer Shirley-Ann, Watson David, Karapanagiotidis Theodoros, Smallwood Jonathan, Jefferies Elizabeth
Department of Psychology and York Neuroimaging Centre, University of York, UK.
Department of Psychology and York Neuroimaging Centre, University of York, UK.
Neuroimage. 2017 Feb 15;147:19-31. doi: 10.1016/j.neuroimage.2016.11.067. Epub 2016 Nov 28.
Words activate cortical regions in accordance with their modality of presentation (i.e., written vs. spoken), yet there is a long-standing debate about whether patterns of activity in any specific brain region capture modality-invariant conceptual information. Deficits in patients with semantic dementia highlight the anterior temporal lobe (ATL) as an amodal store of semantic knowledge but these studies do not permit precise localisation of this function. The current investigation used multiple imaging methods in healthy participants to examine functional dissociations within ATL. Multi-voxel pattern analysis identified spatially segregated regions: a response to input modality in anterior superior temporal gyrus (aSTG) and a response to meaning in more ventral anterior temporal lobe (vATL). This functional dissociation was supported by resting-state connectivity that found greater coupling for aSTG with primary auditory cortex and vATL with the default mode network. A meta-analytic decoding of these connectivity patterns implicated aSTG in processes closely tied to auditory processing (such as phonology and language) and vATL in meaning-based tasks (such as comprehension or social cognition). Thus we provide converging evidence for the segregation of meaning and input modality in the ATL.
单词根据其呈现方式（即书面与口头）激活皮质区域，然而，关于任何特定脑区的活动模式是否捕捉到模态不变的概念信息，存在长期的争论。语义性痴呆患者的缺陷突出了前颞叶（ATL）作为语义知识的非模态存储，但这些研究无法精确确定该功能的定位。当前的研究在健康参与者中使用多种成像方法来检查ATL内的功能分离。多体素模式分析确定了空间上分离的区域：前颞上回（aSTG）对输入模态的反应，以及更腹侧的前颞叶（vATL）对意义的反应。静息态连接性支持了这种功能分离，发现aSTG与初级听觉皮层的耦合更强，而vATL与默认模式网络的耦合更强。对这些连接模式的元分析解码表明，aSTG参与了与听觉处理密切相关的过程（如语音学和语言），而vATL参与了基于意义的任务（如理解或社会认知）。因此，我们为ATL中意义和输入模态的分离提供了汇聚证据。
