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超低剂量CT扫描在四肢骨折评估中的应用:采用骨科损伤低剂量CT(REDUCTION)方案降低有效剂量是否有效?

The use of ultra-low-dose CT scans for the evaluation of limb fractures: is the reduced effective dose using ct in orthopaedic injury (REDUCTION) protocol effective?

作者信息

Konda S R, Goch A M, Leucht P, Christiano A, Gyftopoulos S, Yoeli G, Egol K A

机构信息

NYU Hospital for Joint Diseases, 301 East 17th Street, New York, 10003, USA.

Montefiore Medical Center, 111 E 210th St, Bronx, NY 10467, USA.

出版信息

Bone Joint J. 2016 Dec;98-B(12):1668-1673. doi: 10.1302/0301-620X.98B12.BJJ-2016-0336.R1.

Abstract

AIMS

To evaluate whether an ultra-low-dose CT protocol can diagnose selected limb fractures as well as conventional CT (C-CT).

PATIENTS AND METHODS

We prospectively studied 40 consecutive patients with a limb fracture in whom a CT scan was indicated. These were scanned using an ultra-low-dose CT Reduced Effective Dose Using Computed Tomography In Orthopaedic Injury (REDUCTION) protocol. Studies from 16 selected cases were compared with 16 C-CT scans matched for age, gender and type of fracture. Studies were assessed for diagnosis and image quality. Descriptive and reliability statistics were calculated. The total effective radiation dose for each scanned site was compared.

RESULTS

The mean estimated effective dose (ED) for the REDUCTION protocol was 0.03 milliSieverts (mSv) and 0.43 mSv (p < 0.005) for C-CT. The sensitivity (Sn), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of the REDUCTION protocol to detect fractures were 0.98, 0.89, 0.98 and 0.89 respectively when two occult fractures were excluded. Inter- and intra-observer reliability for diagnosis using the REDUCTION protocol (κ = 0.75, κ = 0.71) were similar to those of C-CT (κ = 0.85, κ = 0.82). Using the REDUCTION protocol, 3D CT reconstructions were equivalent in quality and diagnostic information to those generated by C-CT (κ = 0.87, κ = 0.94).

CONCLUSION

With a near 14-fold reduction in estimated ED compared with C-CT, the REDUCTION protocol reduces the amount of CT radiation substantially without significant diagnostic decay. It produces images that appear to be comparable with those of C-CT for evaluating fractures of the limbs. Cite this article: Bone Joint J 2016;98-B:1668-73.

摘要

目的

评估超低剂量CT方案对特定肢体骨折的诊断效果是否与传统CT(C-CT)相同。

患者与方法

我们前瞻性地研究了40例连续的肢体骨折患者,这些患者均需进行CT扫描。对他们采用超低剂量CT的骨科损伤计算机断层扫描降低有效剂量(REDUCTION)方案进行扫描。从16例选定病例的研究结果与16例年龄、性别和骨折类型相匹配的C-CT扫描结果进行比较。对研究结果进行诊断和图像质量评估。计算描述性和可靠性统计数据。比较每个扫描部位的总有效辐射剂量。

结果

REDUCTION方案的平均估计有效剂量(ED)为0.03毫西弗(mSv),C-CT为0.43 mSv(p < 0.005)。排除两处隐匿性骨折后,REDUCTION方案检测骨折的灵敏度(Sn)、特异度(Sp)、阳性预测值(PPV)和阴性预测值(NPV)分别为0.98、0.89、0.98和0.89。使用REDUCTION方案进行诊断的观察者间和观察者内可靠性(κ = 0.75,κ = 0.71)与C-CT(κ = 0.85,κ = 0.82)相似。使用REDUCTION方案时,三维CT重建的质量和诊断信息与C-CT生成的相当(κ = 0.87,κ = 0.94)。

结论

与C-CT相比,REDUCTION方案的估计有效剂量降低了近14倍,在不显著影响诊断效果的情况下大幅减少了CT辐射量。在评估肢体骨折方面,其生成的图像似乎与C-CT相当。引用本文:《骨与关节杂志》2016年;98-B:1668 - 73。

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