Govindaraj Ramar, Paulraj Michael Gabriel, Toppo Erenius, Pandikumar Perumal, Ignacimuthu Savarimuthu, Al-Dhabi Naif Abdhullah
Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India.
Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India; International Scientific Partnership, College of Science, King Saud University, Riyadh, Saudi Arabia.
Int J Med Mushrooms. 2016;18(8):661-669. doi: 10.1615/IntJMedMushrooms.v18.i8.20.
Different concentrations of standardized ethanolic extract from the basidiocarps of Tricholoma giganteum Massee (TgEtOH) were screened for hepatoprotective effects in an animal model of rats with nonalcoholic fatty liver disease (NAFLD) fed a high-fat and high-fructose diet. After 4 weeks of treatment with TgEtOH, the relative liver weights, serum lipid concentrations, and biochemical profiles were found to be normal in treated animals compared with those given a standard drug. The macroscopic and histopathological studies clearly indicated that 200 mg/kg of ethanolic extract was effective in ameliorating the abnormalities of NAFLD. The findings indicate the efficacy of T. giganteum extract in liver protection. Future experiments on bioassay tailored fractionation of TgEtOH and mechanistic-based evaluation are required to assess the potential application of this mushroom as a food supplement in NAFLD.
在喂食高脂高果糖饮食的非酒精性脂肪性肝病（NAFLD）大鼠动物模型中，筛选了不同浓度的巨大口蘑（Tricholoma giganteum Massee）子实体标准化乙醇提取物（TgEtOH）的肝脏保护作用。用TgEtOH治疗4周后，与给予标准药物的动物相比，治疗组动物的相对肝脏重量、血脂浓度和生化指标均恢复正常。大体和组织病理学研究清楚地表明，200mg/kg乙醇提取物对改善NAFLD异常有效。这些发现表明巨大口蘑提取物具有肝脏保护功效。未来需要对TgEtOH进行生物测定导向的分级分离实验以及基于机制的评估，以评估这种蘑菇作为NAFLD食品补充剂的潜在应用。
