Dias Ana Rita, Costa-Rodrigues João, Fernandes Maria Helena, Ferraz Ricardo, Prudêncio Cristina
Ciências Químicas e das Biomoléculas / Centro de Investigação em Saúde e Ambiente (CISA), ESS-Escola Superior de Saúde do Porto do Instituto Politécnico do Porto, Portugal, Rua Dr. António Bernardino de Almeida, 400, 4200-072, Porto, Portugal.
Laboratório de Farmacologia e Biocompatibilidade Celular, Faculdade de Medicina Dentária, Universidade do Porto, Rua Dr. Manuel Pereira da Silva, 4200-393, Porto, Portugal.
ChemMedChem. 2017 Jan 5;12(1):11-18. doi: 10.1002/cmdc.201600480. Epub 2016 Dec 13.
Among the many challenges that the pharmaceutical industry currently faces is the need to develop innovative and effective therapies. The investigation of alternative and effective therapies against cancer is a current goal of the pharmaceutical industry. Ionic liquids (ILs) have emerged recently as a topic of study by researchers in the pharmaceutical industry in their search for new therapeutic agents. By definition, ILs are organic salts with melting points below 100 °C that are composed only by ions. Their main advantage lies in the numerous possible combinations of cations and anions, which allow adjustments in their physicochemical properties. The combination between ILs and active pharmaceutical ingredients (APIs) may improve the properties of APIs. In addition, the antitumor properties of these compounds have been described. Several studies have reported the use of ILs in biomedical applications as therapeutic agents, namely as antitumor agents. This review describes the recent proposed applications of ILs as antitumor agents.
制药行业目前面临的众多挑战之一是需要开发创新且有效的疗法。研究针对癌症的替代有效疗法是制药行业当前的一个目标。离子液体（ILs）最近已成为制药行业研究人员在寻找新治疗剂过程中的一个研究课题。根据定义，离子液体是熔点低于100°C且仅由离子组成的有机盐。它们的主要优势在于阳离子和阴离子有众多可能的组合，这使得它们的物理化学性质能够得到调整。离子液体与活性药物成分（APIs）的结合可能会改善活性药物成分的性质。此外，这些化合物的抗肿瘤特性也已被描述。几项研究报告了离子液体在生物医学应用中作为治疗剂，即作为抗肿瘤剂的用途。本综述描述了离子液体作为抗肿瘤剂最近提出的应用。
