Khullar Vishal, Schaff Hartzell V, Dearani Joseph A, Daly Richard C, Greason Kevin L, Joyce Lyle D, Pochettino Alberto
Division of Cardiovascular Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota.
Division of Cardiovascular Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota.
Ann Thorac Surg. 2017 May;103(5):1413-1420. doi: 10.1016/j.athoracsur.2016.08.064. Epub 2016 Dec 1.
Endovascular arch repair technology is driven in large part by the assumption that open arch operations are high-risk. We wanted to evaluate the clinical results of open arch reconstruction in the modern era in a large group practice.
From October 2003 to June 2014, 567 patients underwent aortic arch operations: hemiarch repair was performed in 429 patients (75.7%; group A), total arch repair in 129 (22.7%; group B), and patch repair in the remaining 9 (1.6%). The procedure was an emergency in 88 patients (20.5%) in group A and in 41 patients (31%) in group B. Redo sternotomy after a previous aortic operation was performed in 35 patients (8.2%) in group A and in 28 patients (22%) in group B.
Permanent neurologic deficits were diagnosed in 12 patients (2.8%) in group A and in 3 patients (2.4%) in group B. No spinal cord injuries occurred. Mortality at 30 days was 4% (17 patients) in group A and 5.4% (7 patients) in group B. Patients in group A were younger than in group B (mean age, 61.3 vs 63.6 years; p = 0.06). Older age (odds ratio, 1.05; 95% confidence interval, 1.01 to 1.09; p = 0.0087) and extracorporeal circulation time (odds ratio, 1.01; 95% confidence interval, 1 to 1.01; p < 0.001) were predictors of perioperative 30-day mortality. Age (odds ratio, 1.05; 95% confidence interval, 1.01 to 1.08; p = 0.006) was the only predictor for neurologic dysfunction. Survival at 2, 6, and 8 years was 90%, 80%, and 69%, respectively, for group A, and 85%, 70% and 62%, respectively, for group B.
These results set a standard against which endovascular technology needs to be compared.
血管内主动脉弓修复技术在很大程度上是基于开放主动脉弓手术风险高这一假设而发展起来的。我们希望在一个大型集体医疗实践中评估现代开放主动脉弓重建的临床结果。
2003年10月至2014年6月,567例患者接受了主动脉弓手术:429例(75.7%;A组)患者进行了半弓修复,129例(22.7%;B组)患者进行了全弓修复,其余9例(1.6%)患者进行了补片修复。A组88例(20.5%)患者和B组41例(31%)患者的手术为急诊手术。A组35例(8.2%)患者和B组28例(22%)患者在先前主动脉手术后进行了再次胸骨切开术。
A组12例(2.8%)患者和B组3例(2.4%)患者被诊断为永久性神经功能缺损。未发生脊髓损伤。A组30天死亡率为4%(17例患者),B组为5.4%(7例患者)。A组患者比B组患者年轻(平均年龄分别为61.3岁和63.6岁;p = 0.06)。年龄较大(比值比,1.05;95%置信区间,1.01至1.09;p = 0.0087)和体外循环时间(比值比,1.01;95%置信区间,1至1.01;p < 0.001)是围手术期30天死亡率的预测因素。年龄(比值比,1.05;95%置信区间,1.01至1.08;p = 0.006)是神经功能障碍的唯一预测因素。A组2年、6年和8年生存率分别为90%、80%和69%,B组分别为85%、70%和62%。
这些结果为血管内技术的比较提供了一个标准。