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胸主动脉夹层腔内修复术:目前制造的支架移植物的解剖学适应证和用于腔内 Bentall 手术的带瓣支架移植物的概念

Endovascular repair in type A aortic dissection: Anatomical candidacy for currently manufactured stent grafts and conceptual valve-carrying devices for an Endo-Bentall procedure.

机构信息

Division of Cardiovascular and Interventional Radiology, Department of Bio-medical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.

Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.

出版信息

Eur J Cardiothorac Surg. 2023 May 2;63(5). doi: 10.1093/ejcts/ezad085.

Abstract

OBJECTIVES

Endovascular treatment has been suggested as an alternative for open surgery for type A aortic dissection, but current devices have severe anatomical limitations. This study assesses the computed tomography-based anatomical suitability of currently manufactured stent grafts as well as 2 embodiments of valve-carrying devices.

METHODS

In a retrospective single-centre cohort of 200 consecutive ascending/arch operations between 2009 and 2018, a total of 112 patients with type A aortic dissections were identified and evaluated for endovascular candidacy based on the locations of the entries, the landing zone diameters/lengths and the supra-aortic vessel origins according to the anatomical instructions for use criteria of 6 commercially available (tubular, branched or fenestrated) stent grafts. Two suggested valve-carrying devices with inner branches or fenestrations for the coronary arteries and branches for the supra-aortic vessels were also evaluated.

RESULTS

The anatomical feasibility for commercial stent grafts ranged from 4% to 21%. The main limitations were proximal landing zone diameter (considering oversizing <15%), length due to dilatation and an entry too close to the sinotubular junction. For the valve-carrying conduits, anatomical feasibility was between 31% and 80%, with the main limiting factors being the diameter of the aortic annulus and its distance to the coronary arteries.

CONCLUSIONS

The anatomical applicability of currently manufactured stent grafts for the treatment of type A aortic dissection is limited mainly by the absence of a suitable proximal landing zone in the ascending aorta and might substantially be improved by anchoring in the aortic annulus using a valve-carrying device that uses either fenestrations or branches for the coronary arteries.

摘要

目的

血管内治疗已被提议作为治疗 A 型主动脉夹层的开放式手术的替代方法,但目前的器械存在严重的解剖学限制。本研究评估了基于计算机断层扫描的目前制造的支架移植物以及 2 种带瓣装置的解剖学适用性。

方法

在 2009 年至 2018 年期间进行的 200 例升主动脉/弓部手术的回顾性单中心队列研究中,根据解剖学使用说明中 6 种市售(管状、分支或开窗)支架移植物的入口位置、着陆区直径/长度以及升主动脉起源,确定并评估了 112 例 A 型主动脉夹层患者的血管内候选资格。还评估了 2 种带有冠状动脉内分支或开窗以及用于升主动脉分支的带瓣装置。

结果

商业支架移植物的解剖学可行性为 4%至 21%。主要限制因素是近端着陆区直径(考虑到大尺寸不足 15%)、由于扩张导致的长度以及入口过于靠近窦管交界处。对于带瓣输送管,解剖学可行性在 31%至 80%之间,主要限制因素是主动脉瓣环的直径及其与冠状动脉的距离。

结论

目前制造的支架移植物治疗 A 型主动脉夹层的解剖学适用性主要受到升主动脉中缺乏合适的近端着陆区的限制,通过使用带瓣装置在主动脉瓣环处锚固,利用冠状动脉的开窗或分支,可显著改善这种情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8e9/10206284/a4fd6cda4e27/ezad085f5.jpg

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