Aydin Duygu, Peker Emine G G, Karakurt Meryem D, Gurel Ayşe, Ayyildiz Mustafa, Cevher Şule C, Agar Erdal, Dane Senol
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Clin Invest Med. 2016 Dec 1;39(6):27511.
The purpose of this study was to evaluate the efficacy of Ginkgo biloba extract (EGb 761) on oxidative events of brain in cisplatin-administrated rats.
Rats were divided into four experimental groups: 1) control (n=6); 2) cisplatin (8 mg/kg, intraperitoneally one dose, n=6); 3) EGb 761 (100 mg/kg intraperitoneally for 15 days, n=6); and 4) cisplatin + EGb 761 (n=6). After drug administration, rats were sacrificed and brain tissues were removed. Nitric oxide (NO), malondialdehyde (MDA) and glutathione (GSH) levels were evaluated in brain tissues.
Single dose cisplatin administration significantly increased NO and GSH levels, but decreased MDA levels in brain tissue samples. EGb 761 treatment reversed the effects of cisplatin on NO and GSH levels, but did not affect the decreased MDA levels.
Results of the study indicate that oxidative stress can be an important pathogenetic mechanism of cisplatin-induced neurotoxicity. EGb 761, an standardized extract of G. biloba leaves that has antioxidant properties, may improve the oxidative stress-related neurological side effects of cisplatin.
本研究旨在评估银杏叶提取物（EGb 761）对顺铂给药大鼠脑氧化事件的疗效。
将大鼠分为四个实验组：1）对照组（n = 6）；2）顺铂组（8 mg/kg，腹腔注射一剂，n = 6）；3）EGb 761组（100 mg/kg腹腔注射15天，n = 6）；4）顺铂 + EGb 761组（n = 6）。给药后，处死大鼠并取出脑组织。评估脑组织中一氧化氮（NO）、丙二醛（MDA）和谷胱甘肽（GSH）水平。
单次给予顺铂显著增加了脑组织样本中的NO和GSH水平，但降低了MDA水平。EGb 761处理逆转了顺铂对NO和GSH水平的影响，但未影响降低的MDA水平。
研究结果表明氧化应激可能是顺铂诱导神经毒性的重要发病机制。EGb 761是具有抗氧化特性的银杏叶标准化提取物，可能改善顺铂与氧化应激相关的神经副作用。
