Zuo Wei, Yan Feng, Zhang Bo, Li Jiantao, Mei Dan
1Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
2Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China.
Aging Dis. 2017 Dec 1;8(6):812-826. doi: 10.14336/AD.2017.0615. eCollection 2017 Dec.
The prevalence of degenerative disorders in public health has promoted in-depth investigations of the underlying pathogenesis and the development of new treatment drugs. Ginkgo biloba leaves extract (EGb) is obtained from Ginkgo biloba leaves and has been used for thousands of years. In recent decades, both basic and clinical studies have established the effects of EGb. It is widely used in various degenerative diseases such as cerebrovascular disease, Alzheimer's disease, macroangiopathy and more. Here, we reviewed several pharmacological mechanisms of EGb, including its antioxidant properties, prevention of mitochondrial dysfunctions, and effect on apoptosis. We also described some clinical applications of EGb, such as its effect on neuro and cardiovascular protection, and anticancer properties. The above biological functions of EGb are mainly focused on aging-related disorders, but its effect on other diseases remains unclear. Thus, through this review, we aim to encourage further studies on EGb and discover more potential applications.
退行性疾病在公共卫生领域的流行推动了对其潜在发病机制的深入研究以及新治疗药物的开发。银杏叶提取物（EGb）源自银杏叶，已被使用了数千年。近几十年来，基础研究和临床研究均证实了EGb的作用。它被广泛应用于各种退行性疾病，如脑血管疾病、阿尔茨海默病、大血管病变等。在此，我们综述了EGb的几种药理机制，包括其抗氧化特性、预防线粒体功能障碍以及对细胞凋亡的影响。我们还描述了EGb的一些临床应用，如对神经和心血管的保护作用以及抗癌特性。EGb的上述生物学功能主要集中在与衰老相关的疾病上，但其对其他疾病的影响仍不清楚。因此，通过本综述，我们旨在鼓励对EGb进行进一步研究，并发现更多潜在应用。
