Fich A, Phillips S F, Hakim N S, Brown M L, Zinsmeister A R
Department of Radiology, Mayo Digestive Diseases Center, Rochester, Minnesota.
Dig Dis Sci. 1989 Oct;34(10):1516-20. doi: 10.1007/BF01537103.
We have shown previously that short-chain fatty acids (mixtures of acetic, propionic, and butyric acids; SCFAs) in the proportions found usually in stool water stimulate fasting ileal motility. Based on indirect evidence, we proposed that these motor patterns (bursts of phasic pressure waves that were propagated) would be propulsive, but the capacity of these stimulated patterns of motility to propel contents has not been established directly. Healthy, surviving dogs were provided with motility sensors and a cannula through which SCFAs could be instilled into the ileum. Boluses of SCFAs were much more likely to stimulate phasic bursts of motility than was saline. Scintigraphic studies using a gamma camera showed that the motility stimulated by SCFAs was propulsive and that the ileum was thereby emptied. We also tested whether SCFAs were equally effective stimuli during fasting and after food. SCFAs were equally effective during fasting and soon after food, but in the late postprandial period, when the meal reached the ileum, SCFAs were much less likely to stimulate motility. These observations shed further light on the capacity of the ileum to sense and react to the nature of the contents.
我们之前已经表明，粪便水中常见比例的短链脂肪酸（乙酸、丙酸和丁酸的混合物；SCFAs）可刺激空腹回肠的蠕动。基于间接证据，我们推测这些运动模式（传播的阶段性压力波爆发）具有推进作用，但这些受刺激的蠕动模式推动内容物的能力尚未得到直接证实。为健康存活的狗配备了运动传感器和一根插管，通过该插管可将SCFAs注入回肠。与生理盐水相比，SCFAs团块更有可能刺激阶段性的蠕动爆发。使用伽马相机进行的闪烁扫描研究表明，SCFAs刺激的蠕动具有推进作用，回肠由此排空。我们还测试了SCFAs在空腹和进食后是否具有同等的刺激效果。SCFAs在空腹时和进食后不久具有同等的刺激效果，但在餐后后期，当食物到达回肠时，SCFAs刺激蠕动的可能性要小得多。这些观察结果进一步揭示了回肠感知内容物性质并做出反应的能力。
