Atwoli Lukoye, Stein Dan J, King Andrew, Petukhova Maria, Aguilar-Gaxiola Sergio, Alonso Jordi, Bromet Evelyn J, de Girolamo Giovanni, Demyttenaere Koen, Florescu Silvia, Maria Haro Josep, Karam Elie G, Kawakami Norito, Lee Sing, Lepine Jean-Pierre, Navarro-Mateu Fernando, O'Neill Siobhan, Pennell Beth-Ellen, Piazza Marina, Posada-Villa Jose, Sampson Nancy A, Ten Have Margreet, Zaslavsky Alan M, Kessler Ronald C
Department of Mental Health, Moi University School of Medicine, Eldoret, Kenya.
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Republic of South Africa.
Depress Anxiety. 2017 Apr;34(4):315-326. doi: 10.1002/da.22579. Epub 2016 Dec 6.
Unexpected death of a loved one (UD) is the most commonly reported traumatic experience in cross-national surveys. However, much remains to be learned about posttraumatic stress disorder (PTSD) after this experience. The WHO World Mental Health (WMH) survey initiative provides a unique opportunity to address these issues.
Data from 19 WMH surveys (n = 78,023; 70.1% weighted response rate) were collated. Potential predictors of PTSD (respondent sociodemographics, characteristics of the death, history of prior trauma exposure, history of prior mental disorders) after a representative sample of UDs were examined using logistic regression. Simulation was used to estimate overall model strength in targeting individuals at highest PTSD risk.
PTSD prevalence after UD averaged 5.2% across surveys and did not differ significantly between high-income and low-middle income countries. Significant multivariate predictors included the deceased being a spouse or child, the respondent being female and believing they could have done something to prevent the death, prior trauma exposure, and history of prior mental disorders. The final model was strongly predictive of PTSD, with the 5% of respondents having highest estimated risk including 30.6% of all cases of PTSD. Positive predictive value (i.e., the proportion of high-risk individuals who actually developed PTSD) among the 5% of respondents with highest predicted risk was 25.3%.
The high prevalence and meaningful risk of PTSD make UD a major public health issue. This study provides novel insights into predictors of PTSD after this experience and suggests that screening assessments might be useful in identifying high-risk individuals for preventive interventions.
在跨国调查中,亲人意外死亡(UD)是最常被报告的创伤经历。然而,关于这种经历后的创伤后应激障碍(PTSD)仍有许多有待了解的地方。世界卫生组织世界心理健康(WMH)调查倡议提供了一个解决这些问题的独特机会。
整理了来自19项WMH调查的数据(n = 78,023;加权应答率70.1%)。在对亲人意外死亡的代表性样本进行PTSD的潜在预测因素(受访者的社会人口统计学特征、死亡特征、既往创伤暴露史、既往精神障碍史)研究时使用了逻辑回归。通过模拟来估计针对PTSD风险最高个体的总体模型强度。
各调查中亲人意外死亡后PTSD的患病率平均为5.2%,高收入国家和中低收入国家之间无显著差异。显著的多变量预测因素包括死者为配偶或子女、受访者为女性且认为自己本可以采取措施预防死亡、既往创伤暴露以及既往精神障碍史。最终模型对PTSD具有很强的预测性,估计风险最高的5%受访者中包含了所有PTSD病例的30.6%。预测风险最高的5%受访者中的阳性预测值(即实际患PTSD的高风险个体比例)为25.3%。
PTSD的高患病率和显著风险使亲人意外死亡成为一个重大的公共卫生问题。本研究为这种经历后PTSD的预测因素提供了新的见解,并表明筛查评估可能有助于识别需要预防性干预的高风险个体。