胰腺囊肿液分析
Analysis of Pancreatic Cyst Fluid.
作者信息
Ngamruengphong Saowanee, Lennon Anne Marie
机构信息
Division of Gastroenterology and Hepatology, The Johns Hopkins Medical Institutions, 1800 Orleans Street, Sheikh Zayed Tower, Baltimore, MD 21287, USA.
Division of Gastroenterology and Hepatology, The Johns Hopkins Medical Institutions, 1800 Orleans Street, Sheikh Zayed Tower, Room 7125JB3, Baltimore, MD 21287, USA.
出版信息
Surg Pathol Clin. 2016 Dec;9(4):677-684. doi: 10.1016/j.path.2016.05.010.
Abstract
Pancreatic cysts are extremely common, and are identified in between 2% to 13% on abdominal imaging studies. Most pancreatic cysts are pseudocysts, serous cystic neoplasms, mucinous cystic neoplasms, or intraductal papillary mucinous neoplasms. The management of pancreatic cysts depends on whether a cyst is benign, has malignant potential, or harbors high-grade dysplasia or invasive carcinoma. The diagnosis of pancreatic cysts, and assessment of risk of malignant transformation, incorporates clinical history, computed tomography (CT), magnetic resonance imaging (MRI), endoscopic ultrasound, and fine-needle aspiration of cyst fluid. This article reviews the cyst fluid markers that are currently used, as well as promising markers under development.
摘要
胰腺囊肿极为常见，在腹部影像学检查中发现率为2%至13%。大多数胰腺囊肿为假性囊肿、浆液性囊性肿瘤、黏液性囊性肿瘤或导管内乳头状黏液性肿瘤。胰腺囊肿的处理取决于囊肿是良性、具有恶变潜能、存在高级别异型增生还是浸润性癌。胰腺囊肿的诊断以及恶变风险评估包括临床病史、计算机断层扫描（CT）、磁共振成像（MRI）、内镜超声以及囊肿液细针穿刺。本文综述了目前使用的囊肿液标志物以及正在研发的有前景的标志物。
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本文引用的文献
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Cyst Fluid Glucose is Rapidly Feasible and Accurate in Diagnosing Mucinous Pancreatic Cysts.囊液葡萄糖在诊断黏液性胰腺囊肿方面快速可行且准确。
Am J Gastroenterol. 2015 Jun;110(6):909-14. doi: 10.1038/ajg.2015.148. Epub 2015 May 19.
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Cyst fluid biomarkers for intraductal papillary mucinous neoplasms of the pancreas: a critical review from the international expert meeting on pancreatic branch-duct-intraductal papillary mucinous neoplasms.胰腺导管内乳头状黏液性肿瘤的囊液生物标志物：来自胰腺分支导管内乳头状黏液性肿瘤国际专家会议的批判性综述
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Preoperative GNAS and KRAS testing in the diagnosis of pancreatic mucinous cysts.术前 GNAS 和 KRAS 检测在胰腺黏液性囊腺瘤/囊腺癌诊断中的应用。
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Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas.癌症基因的靶向新一代测序剖析了胰腺导管内乳头状肿瘤的分子特征。
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mAb Das-1 is specific for high-risk and malignant intraductal papillary mucinous neoplasm (IPMN).单抗 Das-1 特异性针对高危和恶性的导管内乳头状黏液性肿瘤（IPMN）。
Gut. 2014 Oct;63(10):1626-34. doi: 10.1136/gutjnl-2013-306219. Epub 2013 Nov 25.
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Branch duct intraductal papillary mucinous neoplasms: does cyst size change the tip of the scale? A critical analysis of the revised international consensus guidelines in a large single-institutional series.分支胰管内导管乳头状黏液性肿瘤：囊肿大小是否改变了病变程度？在大型单机构系列中对修订后的国际共识指南进行的批判性分析。
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