Ruiz-Manriquez Luis M, Ledesma Pacheco Schoenstatt Janin, Medina-Gomez Daniel, Uriostegui-Pena Andrea G, Estrada-Meza Carolina, Bandyopadhyay Anindya, Pathak Surajit, Banerjee Antara, Chakraborty Samik, Srivastava Aashish, Paul Sujay
Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, Mexico.
C4 Rice Center, International Rice Research Institute, Manila 4031, Philippines.
Genes (Basel). 2022 Jan 22;13(2):191. doi: 10.3390/genes13020191.
miRNAs are small endogenous conserved non-coding RNA molecules that regulate post-transcriptional gene expression through mRNA degradation or translational inhibition, modulating nearly 60% of human genes. Cystic diseases are characterized by the presence of abnormal fluid-filled sacs in the body, and though most cysts are benign, they can grow inside tumors and turn malignant. Recent evidence has revealed that the aberrant expression of a number of miRNAs present in extracellular fluids, including plasma or serum, urine, saliva, follicular fluid, and semen, contribute to different cystic pathologies. This review aims to describe the role of different miRNAs in three worldwide relevant cystic diseases: polycystic ovarian syndrome (PCOS), polycystic kidney disease (PKD), and pancreatic cyst tumors (PCTs), as well as their potential use as novel biomarkers.
微小RNA（miRNAs）是一类内源性保守的小非编码RNA分子，它们通过mRNA降解或翻译抑制来调控转录后基因表达，调节近60%的人类基因。囊性疾病的特征是体内出现异常的充满液体的囊，尽管大多数囊肿是良性的，但它们可在肿瘤内生长并恶变。最近的证据表明，存在于细胞外液（包括血浆或血清、尿液、唾液、卵泡液和精液）中的一些miRNAs的异常表达与不同的囊性疾病病理相关。本综述旨在描述不同miRNAs在三种全球相关的囊性疾病：多囊卵巢综合征（PCOS）、多囊肾病（PKD）和胰腺囊肿肿瘤（PCTs）中的作用，以及它们作为新型生物标志物的潜在用途。
