Oshitari Toshiyuki, Ota Satomi, Ooka Emi, Kishimoto Takashi, Ota Satoshi, Baba Takayuki, Yamamoto Shuichi
Department of Ophthalmology and Visual Science.
Department of Molecular Pathology and.
Neuroophthalmology. 2015 Feb 3;39(2):83-87. doi: 10.3109/01658107.2014.997888. eCollection 2015 Apr.
We present a case of orbital mucosa-associated lymphoid tissue (MALT) lymphoma accompanied by a serous retinal detachment (SRD). A 44-year-old man who developed uveitis accompanied by a SRD in the right eye was referred to the Chiba National Hospital. B-mode ultrasonography and magnetic resonance imaging (MRI) showed a thickened choroidal membrane and a retrobulbar mass. Although topical steroid treatments improved the inflammation, the SRD did not improve. He was then referred to the Chiba University Hospital. Two months later, the retrobulbar mass had increased, and a partial resection biopsy combined with flow cytometry was performed. The final diagnosis was MALT lymphoma. After R-CHOP (rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy, signs of the tumour could not be detected and the SRD was reduced. We conclude that the SRD was most likely due to the infiltration of lymphoma cells and also to choroidal circulatory disturbances. Retrobulbar malignant lymphomas associated with a SRD are very rare and difficult to diagnosis without biopsy, but because early diagnosis is helpful in deciding the appropriate therapy, we recommend partial biopsy.
我们报告一例眼眶黏膜相关淋巴组织（MALT）淋巴瘤伴浆液性视网膜脱离（SRD）的病例。一名44岁男性因右眼葡萄膜炎伴SRD被转诊至千叶国立医院。B型超声和磁共振成像（MRI）显示脉络膜增厚和球后肿块。尽管局部使用类固醇治疗改善了炎症，但SRD并未改善。随后他被转诊至千叶大学医院。两个月后，球后肿块增大，进行了部分切除活检并结合流式细胞术检查。最终诊断为MALT淋巴瘤。经R-CHOP（利妥昔单抗-环磷酰胺、多柔比星、长春新碱和泼尼松龙）化疗后，肿瘤迹象无法检测到，SRD减轻。我们得出结论，SRD很可能是由于淋巴瘤细胞浸润以及脉络膜循环障碍所致。与SRD相关的球后恶性淋巴瘤非常罕见，未经活检很难诊断，但由于早期诊断有助于确定合适的治疗方法，我们建议进行部分活检。
