Thandra Abhishek, Jun Bokkwan, Chuquilin Miguel
Department of Neurology, University of Missouri in Columbia , Columbia, Missouri, USA , and.
Department of Ophthalmology, University of Missouri in Columbia , Columbia, Missouri, USA.
Neuroophthalmology. 2015 Jul 15;39(4):179-182. doi: 10.3109/01658107.2015.1044541. eCollection 2015 Aug.
Intracranial hypertension and papilloedema are known to develop secondary to cerebral sinus or bilateral jugular vein thrombosis. However, in rare cases, unilateral jugular vein thrombosis may lead to increased intracranial pressure and papilloedema with resultant headache and vision changes. We describe a 45-year-old patient with squamous cell carcinoma of the larynx that developed right jugular vein thrombosis after chemoradiation therapy with cetuximab. This was later complicated by intracranial hypertension and papilloedema. The normal cerebral venous drainage, the potential role of chemoradiation therapy on the aetiology of jugular vein thrombosis, and the mechanism of increased intracranial pressure secondary to unilateral jugular vein occlusion are discussed.
颅内高压和视乳头水肿已知继发于脑静脉窦或双侧颈静脉血栓形成。然而，在罕见情况下，单侧颈静脉血栓形成可能导致颅内压升高和视乳头水肿，进而引起头痛和视力变化。我们描述了一名45岁喉鳞状细胞癌患者，在接受西妥昔单抗放化疗后发生右侧颈静脉血栓形成。随后并发颅内高压和视乳头水肿。本文讨论了正常的脑静脉引流、放化疗在颈静脉血栓形成病因中的潜在作用以及单侧颈静脉闭塞继发颅内压升高的机制。
