Mendel Thomas, Fleischman David, Allingham R Rand, Tseng Henry, Chesnutt David A
Department of Surgery, University of Virginia , Charlottesville, Virginia, USA.
Department of Ophthalmology, University of North Carolina , Chapel Hill, North Carolina, USA.
Neuroophthalmology. 2016 Apr 29;40(3):139-145. doi: 10.3109/01658107.2016.1173065. eCollection 2016 Jun.
Visual toxicities from ethambutol are rare but represent one of the few causes of non-glaucomatous and non-compressive bitemporal hemianopsia. The authors present a six-patient case series illustrating variable clinical presentation and reversibility of visual loss in patients treated with ethambutol for complex, including four patients who presented with visual field defects suggestive of bitemporal hemianopsia. Two additional patients were being followed for glaucoma, developed visual field defects with ethambutol treatment, and subsequently recovered with cessation of drug. In patients being treated with ethambutol, reversible bitemporal hemianopsia was the most commonly noted presentation of ethambutol toxicity.
乙胺丁醇引起的视觉毒性罕见,但却是非青光眼性和非压迫性双颞侧偏盲的少数病因之一。作者报告了一个6例患者的病例系列,阐述了接受乙胺丁醇治疗的患者临床表现的多样性以及视力丧失的可逆性,其中包括4例出现提示双颞侧偏盲视野缺损的患者。另外2例因青光眼接受随访的患者,在接受乙胺丁醇治疗后出现视野缺损,随后停药后恢复。在接受乙胺丁醇治疗的患者中,可逆性双颞侧偏盲是乙胺丁醇毒性最常见的表现。