Behbehani R S, Affel E L, Sergott R C, Savino P J
Neuro-ophthalmology Service, Wills Eye Hospital, 840 Walnut Street, Philadelphia, PA 19107, USA.
Br J Ophthalmol. 2005 Aug;89(8):976-82. doi: 10.1136/bjo.2004.065656.
To determine the anatomical site and extent of electrophysiological dysfunction in patients with ethambutol associated visual loss.
A comparative case series. Four patients with ethambutol associated visual loss underwent multifocal electroretinography (mERG). Two patients had advanced visual loss while two had early signs of toxicity. The N1-P1, N1, P1 amplitudes, N1, and P1 latencies were compared to 10 age and sex matched controls.
mERG abnormalities were detected in the ethambutol treated patients. The N1 amplitude was significantly lower in the ethambutol treated patients than in the control group.
Ethambutol is possibly toxic to the retina, and not only the optic nerve. The multifocal ERG may be of value to diagnose and monitor patients taking ethambutol.
确定乙胺丁醇所致视力丧失患者电生理功能障碍的解剖部位及程度。
一项对比病例系列研究。4例乙胺丁醇所致视力丧失患者接受了多焦视网膜电图（mERG）检查。2例患者有严重视力丧失，2例有早期毒性体征。将N1-P1、N1、P1波幅以及N1、P1潜伏期与10名年龄和性别匹配的对照者进行比较。
在接受乙胺丁醇治疗的患者中检测到mERG异常。接受乙胺丁醇治疗的患者N1波幅明显低于对照组。
乙胺丁醇可能不仅对视神经有毒性，对视网膜也有毒性。多焦视网膜电图可能对诊断和监测服用乙胺丁醇的患者有价值。
