Janahmadi Zeinab, Nekooeian Ali Akbar, Moaref Ali Reza, Emamghoreishi Masoomeh
Cardiovascular Pharmacology Research Lab, Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran.
Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2017 Mar;390(3):245-252. doi: 10.1007/s00210-016-1323-6. Epub 2016 Dec 8.
Much of the beneficial effects of olive products have been attributed to oleuropein. This study examined the effects of oleuropein in rats with heart failure induced by permanent ligation of left coronary arteries. Twenty-four hours after the operation, the rats were assigned to five groups including a sham assigned to receive vehicle (1 ml/day) and four coronary ligated groups assigned to receive vehicle or oleuropein at 5, 10, or 20 mg/kg/day. Five weeks later, echocardiographic and hemodynamic parameters, serum concentrations of oxidative stress, and inflammatory markers were determined. Myocardial infarction group receiving vehicle showed impaired hemodynamic and echocardiographic parameters as evidenced by decreased left ventricular systolic pressure, rate of rise and decrease of left ventricular pressure, stroke volume, ejection fraction, and cardiac output. In addition, significant reduction in superoxide dismutase and glutathione reductase was observed. Oleuropein treatment prevented the reduction of these variables. Moreover, the group had a significantly higher infarct size and serum malondialdehyde, interleukin-1β, and tumor necrosis factor-α than those of the sham group. Treatment with oleuropein prevented the increase of these variables. The results show that oleuropein attenuates the progression of heart failure, possibly by antioxidative and antiinflammatory effects.
橄榄产品的许多有益作用都归因于橄榄苦苷。本研究考察了橄榄苦苷对永久性结扎左冠状动脉所致心力衰竭大鼠的影响。术后24小时，将大鼠分为五组，包括假手术组，给予赋形剂（1毫升/天），以及四组冠状动脉结扎组，分别给予赋形剂或5、10或20毫克/千克/天的橄榄苦苷。五周后，测定超声心动图和血流动力学参数、氧化应激血清浓度以及炎症标志物。接受赋形剂的心肌梗死组显示血流动力学和超声心动图参数受损，表现为左心室收缩压、左心室压力上升和下降速率、每搏输出量、射血分数和心输出量降低。此外，超氧化物歧化酶和谷胱甘肽还原酶显著降低。橄榄苦苷治疗可防止这些变量的降低。此外，该组梗死面积以及血清丙二醛、白细胞介素-1β和肿瘤坏死因子-α显著高于假手术组。橄榄苦苷治疗可防止这些变量的增加。结果表明，橄榄苦苷可能通过抗氧化和抗炎作用减轻心力衰竭的进展。
