Khalili Azadeh, Nekooeian Ali Akbar, Khosravi Mohammad Bagher
a Department of Physiology and Pharmacology, School of Medicine , Alborz University of Medical Sciences , Karaj 3146883811 , Iran.
b Cardiovascular Pharmacology, Research Lab, Department of Pharmacology, School of Medicine , Shiraz University of Medical Sciences , Shiraz 7134845794 , Iran.
J Asian Nat Prod Res. 2017 Oct;19(10):1011-1021. doi: 10.1080/10286020.2017.1307834. Epub 2017 Mar 28.
Oleuropein mediates most of the beneficial effects of olive products. This study examined the role of oxidative stress in the effects of oleuropein on lipid profile and blood glucose in rats with simultaneous renovascular hypertension and type 2 diabetes. Eight groups (n = 7-9 each) of male Sprague-Dawley rats including a control, a type 2 diabetic, a renovascular hypertensive, a sham, a simultaneously hypertensive diabetic receiving vehicle, and 3 simultaneously hypertensive-diabetic receiving 20, 40, or 60 mg/kg/day oleuropein were used. Four weeks after treatment, blood glucose, lipid profile, and biomarkers of oxidative stress were measured, and glucose tolerance test (GTT) was performed. Simultaneously hypertensive diabetic rats had significantly higher blood pressure, blood glucose, and serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride and malondialdehyde. They also had lower serum high-density lipoprotein cholesterol, erythrocyte superoxide dismutase, and impaired glucose tolerance. Oleuropein significantly reduced blood pressure, blood glucose, and serum total cholesterol, LDL-C, triglyceride and malondoaldehyde. It also increased serum high-density lipoprotein cholesterol, erythrocyte superoxide dismutase, and improved glucose tolerance. The findings show that the model is associated with impaired glucose tolerance, and adverse lipid profile. They also show that oleuropein, partly by an antioxidant mechanism, improves glucose tolerance and changed lipid profile favorably.
橄榄苦苷介导了橄榄产品的大部分有益功效。本研究探讨了氧化应激在橄榄苦苷对同时患有肾血管性高血压和2型糖尿病大鼠的血脂和血糖影响中的作用。使用了八组雄性斯普拉格-道利大鼠（每组n = 7 - 9只），包括对照组、2型糖尿病组、肾血管性高血压组、假手术组、同时患有高血压和糖尿病且接受载体的组，以及3组同时患有高血压和糖尿病且分别接受20、40或60 mg/kg/天橄榄苦苷的组。治疗四周后，测量血糖、血脂谱和氧化应激生物标志物，并进行葡萄糖耐量试验（GTT）。同时患有高血压和糖尿病的大鼠血压、血糖、血清总胆固醇、低密度脂蛋白胆固醇（LDL-C）、甘油三酯和丙二醛显著升高。它们的血清高密度脂蛋白胆固醇、红细胞超氧化物歧化酶也较低，且葡萄糖耐量受损。橄榄苦苷显著降低了血压、血糖、血清总胆固醇、LDL-C、甘油三酯和丙二醛。它还增加了血清高密度脂蛋白胆固醇、红细胞超氧化物歧化酶，并改善了葡萄糖耐量。研究结果表明，该模型与葡萄糖耐量受损和不良血脂谱有关。它们还表明，橄榄苦苷部分通过抗氧化机制改善了葡萄糖耐量并有利地改变了血脂谱。
