Castrogiovanni Paola, Trovato Francesca Maria, Loreto Carla, Nsir Houda, Szychlinska Marta Anna, Musumeci Giuseppe
Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, 95100 Catania, Italy.
Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy.
Int J Mol Sci. 2016 Dec 6;17(12):2042. doi: 10.3390/ijms17122042.
Nutraceuticals are dietary compounds which have a role in the balance of anabolic and catabolic signals in joints. Their regulatory function on homeostasis of cartilage metabolism nutraceuticals is increasingly considered for the management and, above all, the prevention of osteoarthritis (OA). OA is a degenerative disease characterized by cartilage and synovium inflammation that can cause joint stiffness, swelling, pain, and loss of mobility. It is a multifactorial disease and, due to the great percentage of people suffering from it and the general increase in life expectancy, OA is considered as one of the most significant causes of disability in the world. OA impairs the structural integrity of articular cartilage that greatly depends on a balance between the anabolic and catabolic processes which occur in chondrocytes and synovial fluid of the joints, therefore the integration with nutraceutical compounds in diet increases the treatment options for patients with established OA beyond traditional rehabilitation, medications, and surgical strategies. In our review, with respect to the current literature, we highlight some of many existing nutraceutical compounds that could be used as integrators in a daily diet thanks to their easy availability, such as in olive oil, fish oil, and botanical extracts used as non-pharmacologic treatment.
营养保健品是一类膳食化合物，在关节合成代谢和分解代谢信号的平衡中发挥作用。它们对软骨代谢稳态的调节功能越来越多地被用于骨关节炎（OA）的管理，尤其是预防。OA是一种退行性疾病，其特征是软骨和滑膜炎症，可导致关节僵硬、肿胀、疼痛和活动能力丧失。这是一种多因素疾病，由于患病人数众多且预期寿命普遍增加，OA被认为是世界上导致残疾的最重要原因之一。OA会损害关节软骨的结构完整性，而这在很大程度上取决于关节软骨细胞和滑液中合成代谢和分解代谢过程之间的平衡，因此，在饮食中添加营养保健品化合物，除了传统的康复、药物和手术策略外，还增加了OA患者的治疗选择。在我们的综述中，结合当前文献，我们重点介绍了许多现有的营养保健品化合物中的一些，由于它们易于获取，例如橄榄油、鱼油和用作非药物治疗的植物提取物，因此可以用作日常饮食中的补充剂。
