Miyazaki T, Yashiki M, Kojima T, Chikasue F, Ochiai A, Hidani Y
Department of Legal Medicine, Hiroshima University School of Medicine, Japan.
Forensic Sci Int. 1989 Aug;42(3):263-70. doi: 10.1016/0379-0738(89)90094-7.
A 79-year-old man and his 73-year-old wife attempted double suicide by ingesting methomyl powder. The woman died 19 h after ingestion in spite of intensive care. At autopsy a large number of miliary hemorrhages were found in both thalami of the brain. Her husband, however, recovered after 10 days of treatment. Methomyl (CAS No. 16752-77-5, Lannate) in the biological materials was analyzed by gas chromatography-mass spectrometry. The methomyl concentration was 44 micrograms/g in the wife's serum sample collected 1 h after ingestion, and 0.2 microgram/g in the blood sample collected at autopsy. The methomyl concentration in the husband's blood sample collected 28 h after ingestion was from 0.01 to 0.1 microgram/g. It is suggested that prompt and adequate intensive care including a direct hemoperfusion is necessary to effect the recovery of patients with lethal blood levels of methomyl. The miliary hemorrhages found in the thalami of the brain are suspected to have been caused by asphyxia induced by methomyl intoxication.
一名79岁男子和他73岁的妻子试图通过吞食灭多威粉末进行双重自杀。尽管进行了重症监护，该女子在摄入后19小时死亡。尸检时发现大脑双侧丘脑有大量粟粒状出血。然而，她的丈夫在治疗10天后康复。采用气相色谱-质谱法分析生物材料中的灭多威（化学物质登记号：16752-77-5，万灵）。摄入后1小时采集的妻子血清样本中灭多威浓度为44微克/克，尸检时采集的血液样本中为0.2微克/克。摄入后28小时采集的丈夫血液样本中灭多威浓度为0.01至0.1微克/克。提示对于血液中灭多威达到致死水平的患者，及时且充分的重症监护包括直接血液灌流对于实现康复是必要的。大脑丘脑中发现的粟粒状出血怀疑是由灭多威中毒引起的窒息所致。
