Roeser H P, Stocks A E, Smith A J
Aust N Z J Med. 1978 Jun;8(3):250-4. doi: 10.1111/j.1445-5994.1978.tb04518.x.
Testicular function was assessed in 32 patients who received standard chemotherapy regimens for disseminated lymphomas. Thirty-one had evidence of germ cell damage, as assessed by the finding of azoospermia and/or high plasma levels of follicle-stimulating hormone (FSH). In addition, five patients had persistently low plasma testosterone levels associated in three with elevated plasma luteinising hormone (LH) levels. Reproductive function did not recover in any patient while chemotherapy continued. Cessation of therapy was possible in 16 patients with prolonged remissions of disease. Among these, recovery of germinal epithelium differed greatly between the cyclophosphamide / vincristine / prednisone treated group and the mustine/procarbazine/vincristine/prednisone treated group. Seventy per cent of the former patients had evidence of recovery after 34 months of follow-up while only one (17%) of the latter had begun to recover at 52 months post-therapy. Serial measurement of plasma FSH levels proved useful in predicting likely recovery of spermatogenesis.
对32例接受弥漫性淋巴瘤标准化疗方案的患者的睾丸功能进行了评估。通过无精子症和/或高血浆促卵泡激素（FSH）水平的检测，31例患者有生殖细胞损伤的证据。此外，5例患者血浆睾酮水平持续偏低，其中3例血浆促黄体生成素（LH）水平升高。在化疗持续期间，没有任何患者的生殖功能恢复。16例疾病长期缓解的患者得以停止治疗。其中，环磷酰胺/长春新碱/泼尼松治疗组与生氮芥/丙卡巴肼/长春新碱/泼尼松治疗组之间生精上皮的恢复情况差异很大。在随访34个月后，前一组70%的患者有恢复的证据，而后一组在治疗后52个月只有1例（17%）开始恢复。血浆FSH水平的系列测量被证明有助于预测精子发生可能的恢复情况。
