串联索普反应/钯催化不对称烯丙基烷基化：以优异的对映选择性合成手性β-烯胺腈
Tandem Thorpe Reaction/Palladium Catalyzed Asymmetric Allylic Alkylation: Access to Chiral β-enaminonitriles with Excellent Enantioselectivity.
作者信息
Bai Da-Chang, Liu Xiu-Yan, Li Hao, Ding Chang-Hua, Hou Xue-Long
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS), 345 Lingling Road, Shanghai, 200032, China.
Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS), Shanghai, 200032, China.
出版信息
Chem Asian J. 2017 Jan 17;12(2):212-215. doi: 10.1002/asia.201601571. Epub 2016 Dec 21.
A new type of nucleophile, a 3-imino nitrile carbanion generated in situ by Thorpe reaction of acetonitrile with a base, was developed successfully and applied in a Pd-catalyzed asymmetric allylic alkylation with mono-substituted allyl reagents under Pd/SIOCPhox catalysis, affording β-enaminonitrile products in high yields with excellent regio- and enantioselectivities.
一种新型亲核试剂，即通过乙腈与碱的索普反应原位生成的3-亚氨基腈碳负离子，已成功开发，并应用于在Pd/SIOCPhox催化下与单取代烯丙基试剂进行的钯催化不对称烯丙基烷基化反应中，以高收率、优异的区域选择性和对映选择性得到β-烯胺腈产物。
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