Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
School of Physical Science and Technology, ShanghaiTech University , 100 Haike Road, Shanghai 201210, China.
Org Lett. 2016 Nov 18;18(22):5912-5915. doi: 10.1021/acs.orglett.6b03013. Epub 2016 Nov 9.
An atom-economical method for radical (phenylsulfonyl)difluoromethylation of isocyanides with PhSOCFH under transition-metal-free conditions has been developed. A PhSOCF radical is generated through the oxidation of PhSOCF after the deprotonation of PhSOCFH in one pot. The reaction exhibits excellent functional-group tolerance and the resulting products can be further modified with the removal of a PhSO group to give other CF-containing compounds.
发展了一种在无过渡金属条件下通过异氰化物的自由基（苯磺酰基）二氟甲基化的原子经济性方法。PhSOCFH 在脱质子后，通过 PhSOCF 的氧化生成 PhSOCF 自由基。该反应表现出优异的官能团容忍性，并且所得产物可以通过去除 PhSO 基团进一步修饰，得到其他含 CF 的化合物。
