Patil D P, Ajantha G S, Shubhada C, Jain P A, Kalabhavi A, Shetty P C, Hosamani M, Appannanavar S, Kulkarni R D
Department of Microbiology, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India.
Indian J Med Microbiol. 2016 Oct-Dec;34(4):427-432. doi: 10.4103/0255-0857.195372.
Brucellosis is an important zoonotic disease. India having a major agrarian population is expected to have a higher prevalence. However, due to lack of laboratory facility or awareness among clinicians, the disease is largely underreported. The aim of this study was to know the prevalence and trend of human brucellosis over a decade, in patients attending a teaching hospital in North Karnataka, and to understand their geographical distribution.
The study was conducted from January 2006 to December 2015 at a tertiary care teaching hospital in North Karnataka. A total of 3610 serum samples were evaluated from suspected cases of brucellosis. All serum samples were initially screened by Rose Bengal plate test, and positive samples were further analysed by Serum agglutination test (SAT) using standard Brucella abortus antigen from Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India. A titre above or equal to 1:80 IU/ml was considered as positive. Demographic data such as age, sex and native place of these patients were also analysed.
We observed that human brucellosis is present in North Karnataka. The overall seropositivity of brucellosis in suspected cases was 5.1%. The positive titres ranged from 1:80 to 163,840 IU/ml. The majority of the patients were from Gadag, Koppal and Haveri districts of North Karnataka.
Our study confirms the presence of human brucellosis in the northern part of Karnataka. Further studies to understand the prevalence of animal brucellosis in these areas will help in implementing prevention measures.
布鲁氏菌病是一种重要的人畜共患病。印度农业人口众多，预计该病患病率较高。然而，由于缺乏实验室设施或临床医生意识不足，该病在很大程度上报告不足。本研究的目的是了解在北卡纳塔克邦一家教学医院就诊的患者中，人类布鲁氏菌病在十年间的患病率及趋势，并了解其地理分布情况。
本研究于2006年1月至2015年12月在北卡纳塔克邦的一家三级护理教学医院进行。共对3610份布鲁氏菌病疑似病例的血清样本进行了评估。所有血清样本最初采用虎红平板凝集试验进行筛查，阳性样本进一步使用来自印度北方邦伊扎特纳加尔印度兽医研究所的标准流产布鲁氏菌抗原，通过血清凝集试验（SAT）进行分析。滴度高于或等于1:80 IU/ml被视为阳性。还分析了这些患者的年龄、性别和籍贯等人口统计学数据。
我们观察到北卡纳塔克邦存在人类布鲁氏菌病。疑似病例中布鲁氏菌病的总体血清阳性率为5.1%。阳性滴度范围为1:80至163,840 IU/ml。大多数患者来自北卡纳塔克邦的加达格、科帕尔和哈维里地区。
我们的研究证实了卡纳塔克邦北部存在人类布鲁氏菌病。进一步研究这些地区动物布鲁氏菌病的患病率将有助于实施预防措施。
