Al-Zaydani I A, Al-Hakami A, Kumar A, Abdalla S A, Otaif M, Thiqa Rma, Ahmed H, Alnahili K
Department of Paediatric, Aseer Central Hospital, Abha 31421, Kingdom of Saudi Arabia.
Department of Microbiology, College Of Medicine, King Khalid University, Abha 31421, Kingdom of Saudi Arabia.
Indian J Med Microbiol. 2016 Oct-Dec;34(4):553-557. doi: 10.4103/0255-0857.195352.
A 5-year-old female child presented with fever of 1-week duration after visiting a malaria endemic zone without antimalarial prophylaxis. The patient presented with respiratory distress, decreased level of consciousness and high-grade fever. An elevated parasitaemia reaching 800,000/μl was observed. Antimalarial therapy was initiated with artesunate being administered intravenous (IV) along with IV clindamycin. Contrary to the expectations, there was no resolution of fever. Following a week of unresolved fever, the drug therapy was revised and altered to IV quinine dihydrochloride and IV clindamycin. Emergence of non-responsiveness to artesunate in Saudi Arabia is an alarming sign and requires revision of management protocols.
一名5岁女童在前往疟疾流行区且未进行疟疾预防治疗后，出现了持续1周的发热症状。该患者表现出呼吸窘迫、意识水平下降和高热。观察到疟原虫血症升高，达到800,000/μl。开始进行抗疟治疗，静脉注射青蒿琥酯并联合静脉注射克林霉素。与预期相反，发热并未消退。在持续1周发热未缓解后，调整药物治疗方案为静脉注射二盐酸奎宁和静脉注射克林霉素。在沙特阿拉伯出现对青蒿琥酯无反应的情况是一个警示信号，需要修订管理方案。
