Papadopoulos G, Randall J, Templeton A A
Department of Obstetrics and Gynaecology, University of Aberdeen, Foresterhill, UK.
Hum Reprod. 1989 Jul;4(5):568-73. doi: 10.1093/oxfordjournals.humrep.a136945.
Data on first trimester human abortions have shown chromosome aberrations in approximately 50% of the cases, most of which were trisomies. More than 80% of these trisomies have been attributed to an error in the oocyte. In this study we investigated the frequency of chromosome anomalies in 44 human unfertilized oocytes and 13 uncleaved zygotes after insemination in vitro. The oocytes were aspirated from preovulatory follicles in parous volunteer donors and patients participating in an embryo replacement programme. Thirty cases could be analysed, 18 of which (60%) carried a chromosome abnormality. There were two hyperhaploidies (6.7%), four hypohaploidies (13.3%), three polyploidies (10%), six with structural aberrations (20%) and five diploidies (16.7%). The incidence of these abnormalities, except for the structural anomalies, was similar to that reported previously. The higher frequency of structural aberrations in the present study may be related to delayed cytogenetic analysis for up to 48 h after insemination.
关于孕早期人工流产的数据显示，约50%的病例存在染色体畸变，其中大多数为三体性。这些三体性中超过80%归因于卵母细胞的错误。在本研究中，我们调查了44个人类未受精卵母细胞和13个体外受精后未分裂的合子中染色体异常的频率。卵母细胞是从经产妇志愿者供体和参与胚胎置换计划的患者的排卵前卵泡中抽吸的。30个病例可供分析，其中18个（60%）存在染色体异常。有2个超单倍体（6.7%）、4个亚单倍体（13.3%）、3个多倍体（10%）、6个有结构畸变（20%）和5个二倍体（16.7%）。除结构异常外，这些异常的发生率与先前报道的相似。本研究中结构畸变的较高频率可能与受精后长达48小时的细胞遗传学分析延迟有关。
