Tejada M I, Mendoza M R, Corcóstegui B, Benito J A
Departamento de Obstetricia y Ginecología, Hospital de Cruces, Vizcaya, Spain.
J Assist Reprod Genet. 1992 Feb;9(1):61-7. doi: 10.1007/BF01204117.
From January 1989 to July 1990 a total of 562 oocytes was fixed in our In Vitro Fertilization Program, while cytogenetic data were collected in the case of 433. Forty-eight of these (11%) had a set of oocyte chromosomes in metaphase II, and at least one other set of sperm chromosomes prematurely condensed in the form of single chromatids. In the literature this phenomenon, frequent in our experience, has not been separately studied by many authors. Comparative studies with diverse parameters have shown a significant correlation between the same phenomenon and the use of follicle-stimulating hormone supplementation in ovarian stimulation protocols. Also, in some cases we found a high percentage of repetition of the phenomenon in one patient.
1989年1月至1990年7月，在我们的体外受精项目中，共固定了562个卵母细胞，同时收集了433例的细胞遗传学数据。其中48例（11%）的卵母细胞染色体处于中期II，并且至少有另一组精子染色体以单染色单体的形式过早凝聚。据我们的经验，这种现象很常见，但在文献中，许多作者并未对其进行单独研究。对不同参数的比较研究表明，同一现象与在卵巢刺激方案中使用促卵泡激素补充剂之间存在显著相关性。此外，在某些情况下，我们发现一名患者中该现象的重复发生率很高。
