Kondratjeva Jevgenija, Pressanti Charline, Reynolds Brice S, Trumel Catherine, Delverdier Maxence, Normand Anne-Cécile, Soetart Nicolas, Guillot Jacques, Cadiergues Marie Christine
Department of Clinical Sciences, University of Toulouse, ENVT, Toulouse, France.
InTheRes, University of Toulouse, INRAE, ENVT, Toulouse, France.
JFMS Open Rep. 2023 Apr 26;9(1):20551169231164610. doi: 10.1177/20551169231164610. eCollection 2023 Jan-Jun.
A 3-year-old neutered domestic shorthair cat with a long history of idiopathic immune-mediated haemolytic anaemia and thrombocytopenia treated with ciclosporin and prednisolone was referred 2 months after the appearance of nodular dermatitis. A single pigmented nodule was present in the lateral carpal region of the right foreleg. The lesion was 7 mm in diameter, non-exudative and cutaneous to subcutaneous. Fine-needle aspiration of the mass revealed the presence of pigmented fungal elements. Excisional surgery was planned; in the meantime, a plaque-like lesion developed in the interorbital region. Histopathological examination confirmed the presumptive diagnosis of phaeohyphomycosis, and was identified as the aetiological agent. Itraconazole, given orally at a dose of 10 mg/kg for 8 weeks following surgery, enabled clinical resolution despite continued use of immunosuppressants. The follow-up was carried out over 14 weeks.
This case report provides the first evidence of multifocal cutaneous phaeohyphomycosis caused by with clinical resolution after combined surgical and itraconazole treatment in an immunocompromised cat.
一只3岁已绝育的家养短毛猫，有特发性免疫介导性溶血性贫血和血小板减少症的长期病史，一直用环孢素和泼尼松龙治疗，在出现结节性皮炎2个月后前来就诊。右前肢腕外侧区域有一个单一的色素沉着结节。病变直径7毫米，无渗出，累及皮肤至皮下组织。对肿块进行细针穿刺抽吸，发现有色素沉着的真菌成分。计划进行切除手术；与此同时，眶间区域出现了一个斑块样病变。组织病理学检查证实了拟诊的暗色丝孢霉病，并确定了病原体。术后口服伊曲康唑，剂量为10毫克/千克，持续8周，尽管继续使用免疫抑制剂，但临床症状仍得到缓解。随访持续了14周。
本病例报告提供了首例由[病原体名称未给出]引起的多灶性皮肤暗色丝孢霉病的证据，该免疫受损猫经手术和伊曲康唑联合治疗后临床症状得到缓解。
