Nasry Sherine A, El Shenawy Hanaa M, Mostafa Dina, Ammar Nagwa M
Professor. Department of Oral Surgery and Medicine, National Research Centre, Giza, Egypt.
Associate Professor. Department of Pharmaceutical Technology, National Research Centre, Giza, Egypt.
J Clin Exp Dent. 2016 Dec 1;8(5):e517-e522. doi: 10.4317/jced.52877. eCollection 2016 Dec.
The underlying etiology of recurrent aphthous stomatitis (RAS) is unclear and treatment aims to provide symptomatic and faster relief. This study compared the efficacy of diode laser, a herbal combination of Acacia nilotica and Licorice (A and L) and Amlexanox in the management of RAS.
Sixty patients with minor aphthae were selected and randomly divided into four groups of 15 each. Group I and II received adhesive preparations of a herbal mixture of A and L and a 2 mg Amlexanox paste respectively, group III received diode laser and the fourth group (control) used a placebo. Ulcer size, pain score were recorded on days 1, 2 and 5.
Laser group showed the statistically highest mean percentage (%) of reduction in pain scores and ulcer size than the other groups. The mean % of reduction in pain scores was 43.3+20.0 at day 2 and 67.8+21.5 % at day 5 in the laser group while Amlexanox group demonstrated a 29.8 +11.3 and 61.9+24.5 mean % of reduction in pain scores at day 2 and 5 respectively. A and L group showed a lower mean % of reduction in pain scores than laser and Amlexanox groups with a 22.2+10.5 and 43.4+15.8 mean % reduction in pain scores at day 2 and day 5 respectively. Similarly the highest mean % of reduction in ulcer size was seen in the laser group being 52.7+19.8 at day 2 and 85.1+22.0 at day 5, while it was 48.1+16.5 at day 2 and 77.8+28.7 at day 5 in the Amlexanox group and 42.0+11.5 at day 2 and 63.0+20.5 at day 5 in the A and L group.
All treatment modalities reduced pain and ulcer size than placebo group. Laser therapy demonstrated the highest percentage of reduction of pain score and ulcer size. Aphthous stomatitis, laser, herbal plants, Acacia nilotica, Licorice.
复发性阿弗他口炎（RAS）的潜在病因尚不清楚，治疗旨在提供症状缓解并更快减轻痛苦。本研究比较了二极管激光、阿拉伯胶和甘草的草药组合（A和L）以及氨来呫诺在RAS治疗中的疗效。
选取60例轻型阿弗他溃疡患者，随机分为四组，每组15例。第一组和第二组分别接受A和L的草药混合物的黏附制剂和2mg氨来呫诺糊剂，第三组接受二极管激光治疗，第四组（对照组）使用安慰剂。在第1、2和5天记录溃疡大小、疼痛评分。
激光组在疼痛评分和溃疡大小的平均降低百分比方面，在统计学上高于其他组。激光组在第2天疼痛评分的平均降低百分比为43.3 + 20.0，在第5天为67.8 + 21.5%，而氨来呫诺组在第2天和第5天疼痛评分的平均降低百分比分别为29.8 + 11.3和61.9 + 24.5。A和L组在疼痛评分的平均降低百分比方面低于激光组和氨来呫诺组，在第2天和第5天疼痛评分的平均降低百分比分别为22.2 + 10.5和43.4 + 15.8。同样，溃疡大小平均降低百分比最高的是激光组，在第2天为52.7 + 19.8，在第5天为85.1 + 22.0，而氨来呫诺组在第2天为48.1 + 16.5，在第5天为77.8 + 28.7，A和L组在第2天为42.0 + 11.5，在第5天为63.0 + 20.5。
与安慰剂组相比，所有治疗方式均能减轻疼痛和缩小溃疡大小。激光治疗在疼痛评分和溃疡大小的降低百分比方面最高。阿弗他口炎、激光、草药、阿拉伯胶、甘草。
