Kavita Kumari, Singh Rohit, Singh Revati, Gonuguntla Sudhir, Luke Alexander Maniangat, Jois Harshvardhan Shridhar
Department of Dentistry, Nalanda Medical College and Hospital, Patna, Bihar, India.
Department of Prosthodontics, Crown, Bridge and Implantology, Patna Dental College & Hospital, Patna, Bihar, India.
J Pharm Bioallied Sci. 2020 Aug;12(Suppl 1):S444-S447. doi: 10.4103/jpbs.JPBS_133_20. Epub 2020 Aug 28.
The aim of this study was to assess the efficacy of 5% topical amlexanox and 0.1% topical triamcinolone acetonide in recurrent aphthous stomatitis (RAS) management.
Sixty adult patients of RAS of both genders were divided into two groups with each group having 30 patients. In group I, 0.1% topical triamcinolone acetonide was prescribed. In group II, 5% topical amlexanox was prescribed. Patients were recalled regularly and size of ulcer, erythema, and pain score was recorded on days 1, 3, and 5.
The mean ulcer size (mm) on day 1 in group I was 4.3 and in group II it was 4.1, on day 3 it was 3.5 in group I and in group II it was 3.6, on day 5 in group I it was 1.3 and in group II it was 1.7. The result was not statistically significant ( > 0.05). The mean pain score recorded on visual analog scale was in descending grade day by day on first, third, and fifth days. In group I, healing was seen in 29 (96.6%) patients and in 28 (93.3%) patients in group II. Partially healing was seen in 1 (3.3%) patient in each group, whereas in group II nonhealing was observed in 1 (3.3%) patient. The statistical significance was not achieved as > 0.05.
Authors found that above drugs were effective in reducing pain, size of ulcer, erythema, and improving healing in patients with recurrent aphthous stomatitis. There were better results with triamcinolone acetonide as comparison of amlexanox.
本研究旨在评估5%局部用氨来呫诺和0.1%局部用曲安奈德治疗复发性阿弗他口炎（RAS）的疗效。
60例成年RAS患者，男女不限，分为两组，每组30例。第一组患者使用0.1%局部用曲安奈德，第二组患者使用5%局部用氨来呫诺。定期召回患者，并在第1、3和5天记录溃疡大小、红斑情况和疼痛评分。
第一组第1天的平均溃疡大小（mm）为4.3，第二组为4.1；第3天第一组为3.5，第二组为3.6；第5天第一组为1.3，第二组为1.7。结果无统计学意义（>0.05）。在视觉模拟量表上记录的平均疼痛评分在第1、3和5天逐日下降。第一组有29例（96.6%）患者愈合，第二组有28例（93.3%）患者愈合。每组各有1例（3.3%）患者部分愈合，而第二组有1例（3.3%）患者未愈合。由于>0.05，未达到统计学意义。
作者发现上述药物在减轻复发性阿弗他口炎患者的疼痛、溃疡大小、红斑情况及促进愈合方面有效。与氨来呫诺相比，曲安奈德的效果更好。
