Sharma Arvind Kumar, Kumar Amit, Yadav Sharad Kumar, Rahal Anu
Department of Veterinary Microbiology, College of Veterinary Sciences and Animal Husbandry, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura 281001, India.
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences and Animal Husbandry, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura 281001, India.
Vet Med Int. 2014;2014:747042. doi: 10.1155/2014/747042. Epub 2014 Apr 7.
Acacia nilotica is a plant species that is almost ubiquitously found in different parts of the world. Various preparations of it have been advocated in folk medicine for the treatment of tuberculosis, leprosy, smallpox, dysentery, cough, ophthalmia, toothache, skin cancer as astringent, antispasmodic, and aphrodisiac since immemorial times. The present study investigates the antibacterial, antifungal, antiviral, and immunomodulatory potential of hot aqueous extract (HAE) of Acacia nilotica leaves. On dry matter basis, the filtered HAE had a good extraction ratio (33.46%) and was found to have carbohydrates, glycosides, phytosterols, phenolic compounds, saponins, and flavonoids as major constituents. HAE produced dose dependent zone of inhibition against Klebsiella pneumoniae, Pseudomonas aeruginosa, E. coli, Bacillus cereus, Staphylococcus aureus, and Streptococcus uberis and fungal pathogens Aspergillus niger and Aspergillus fumigates; however, no antiviral activity was recorded against IBR virus. HAE of A. nilotica revealed both proliferative and inhibitory effects on the rat splenocytes and IL-10 release depending on the dose. Detailed studies involving wide spectrum of bacterial, fungal, and viral species are required to prove or know the exact status of each constituents of the plant extract.
阿拉伯胶树是一种几乎在世界不同地区都能普遍发现的植物物种。自古以来，其各种制剂在民间医学中就被推荐用于治疗结核病、麻风病、天花、痢疾、咳嗽、眼炎、牙痛、皮肤癌，具有收敛、解痉和壮阳作用。本研究调查了阿拉伯胶树叶热水提取物（HAE）的抗菌、抗真菌、抗病毒和免疫调节潜力。以干物质计，过滤后的HAE具有良好的提取率（33.46%），并发现其主要成分有碳水化合物、糖苷、植物甾醇、酚类化合物、皂苷和黄酮类化合物。HAE对肺炎克雷伯菌、铜绿假单胞菌、大肠杆菌、蜡样芽孢杆菌、金黄色葡萄球菌、乳房链球菌以及真菌病原体黑曲霉和烟曲霉产生剂量依赖性抑菌圈；然而，对传染性牛鼻气管炎病毒未记录到抗病毒活性。阿拉伯胶树的HAE根据剂量对大鼠脾细胞和IL-10释放显示出增殖和抑制作用。需要进行涉及广泛细菌、真菌和病毒种类的详细研究，以证明或了解植物提取物各成分的确切情况。
