Cleutjens Fiona A H M, Pedone Claudio, Janssen Daisy J A, Wouters Emiel F M, Incalzi Raffaele A
Dept of Research and Education, CIRO Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.
Dept of Geriatrics, University Campus Bio-Medico, Rome, Italy.
ERJ Open Res. 2016 Sep 28;2(3). doi: 10.1183/23120541.00054-2016. eCollection 2016 Jul.
Information about the association between cognitive functions, such as copying function, and sleep disturbances in patients with chronic obstructive pulmonary disease (COPD) is lacking. This cross-sectional observational study aimed to investigate the association between copying function and self-reported sleep quality disturbances and disease severity in an elderly COPD population. Cognitive function performances, assessed using the Mini-Mental State Examination, were compared in 562 ambulatory COPD patients with and without sleep disturbances; assessed using the Established Populations for Epidemiologic Studies of the Elderly questionnaire; and stratified by Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades. Sleep disturbances overall were not correlated with cognitive functioning. A trend was revealed towards worse design copying in patients with sleep disturbances overall. GOLD I patients with difficulties falling asleep and nocturnal awakenings had worse copying ability compared to GOLD I patients without these sleep disturbances. Copying ability was worse for GOLD III than GOLD I, orientation was worse for GOLD II than GOLD I and language was worse for GOLD II and III than GOLD I. To conclude, sleep disturbances seem to be a weak correlate of cognitive functioning, and are not a marker of disease severity.
慢性阻塞性肺疾病（COPD）患者认知功能（如抄写功能）与睡眠障碍之间的关联信息尚缺。这项横断面观察性研究旨在调查老年COPD人群中抄写功能与自我报告的睡眠质量障碍及疾病严重程度之间的关联。对562名有或无睡眠障碍的非卧床COPD患者，使用简易精神状态检查表评估其认知功能表现；使用老年人流行病学研究既定人群问卷进行评估；并按慢性阻塞性肺疾病全球倡议（GOLD）分级进行分层。总体而言，睡眠障碍与认知功能无关。总体上，睡眠障碍患者的图案抄写表现有变差的趋势。与无这些睡眠障碍的GOLD I级患者相比，入睡困难和夜间觉醒的GOLD I级患者抄写能力更差。GOLD III级患者的抄写能力比GOLD I级差，GOLD II级患者的定向能力比GOLD I级差，GOLD II级和III级患者的语言能力比GOLD I级差。总之，睡眠障碍似乎与认知功能仅有微弱关联，且并非疾病严重程度的标志。
