Lee H S, Kim S H, Kim I T
Korean J Ophthalmol. 1989 Jun;3(1):6-10. doi: 10.3341/kjo.1989.3.1.6.
The effects of hemocoagulase in injectable form (hemocoagulating enzymatic fraction of South American snake Bothrops jararaca venom provided by Ravizza) on the control of intraocular bleeding during vitreous surgery were evaluated in rabbit eyes. Intraocular infusion solution with hemocoagulase (1 NIH thrombin unit/100 ml of BSS plus) significantly reduced the bleeding time. Electroretinogram b-wave and electroretinogram c-wave showed no abnormality. Infusate with hemocoagulase (1 NIH thrombin unit/100 ml of BSS plus) is not toxic to retinal tissue and appeared to be a useful agent for the control of intraocular bleeding during vitreous surgery.
在兔眼中评估了注射用凝血酶（由拉维扎提供的南美蝰蛇毒液的凝血酶组分）对玻璃体手术中眼内出血控制的效果。含凝血酶的眼内灌注液（1 NIH凝血酶单位/100 ml平衡盐溶液加）显著缩短了出血时间。视网膜电图b波和视网膜电图c波均未显示异常。含凝血酶的灌注液（1 NIH凝血酶单位/100 ml平衡盐溶液加）对视网膜组织无毒，似乎是玻璃体手术中控制眼内出血的有用药物。
