Kim S H, Lee H S, Kim I T, Jung B H, Cho J H, Kwak J S
Department of Ophthalmology, Kyungpook National University Hospital, Taegu, Korea.
Jpn J Ophthalmol. 1993;37(4):379-84.
Hemorrhage during vitrectomy for diabetic retinopathy or in the recently traumatized eye can complicate the surgical procedures and might cause termination and failure of vitrectomy in some cases. The effect of the hemocoagulase, Botropase, on the hemostasis of intraocular bleeding was evaluated in a rabbit model by cutting central retinal vessels in the medullary ray. Addition of the hemocoagulase (1 NIH unit/100 ml) to BSS Plus significantly reduced bleeding time. Immediately after vitrectomy with the use of this hemocoagulase, the average of the maximum amplitudes of the b-wave in electroretinography was normal, although the sensitivity of the electroretinogram was reduced by 0.1 log unit in the experimental eyes which were infused with hemocoagulase solution. The sensitivity showed no significant difference after the second postoperative day. The experimental eyes showed no abnormal findings histologically. Infusate containing Botropase appeared to be a useful adjunct for the control of intraocular bleeding during vitreous surgery.
糖尿病性视网膜病变玻璃体切除术期间或近期受伤眼睛的出血会使手术过程复杂化，在某些情况下可能导致玻璃体切除术终止和失败。通过在髓放线处切断视网膜中央血管，在兔模型中评估了血凝酶（巴曲酶）对眼内出血止血的作用。在平衡盐溶液（BSS Plus）中添加血凝酶（1 NIH单位/100 ml）可显著缩短出血时间。使用这种血凝酶进行玻璃体切除术后立即检查，虽然注入血凝酶溶液的实验眼视网膜电图的敏感性降低了0.1对数单位，但视网膜电图b波最大振幅的平均值正常。术后第二天后敏感性无显著差异。实验眼在组织学上未显示异常发现。含巴曲酶的灌注液似乎是玻璃体手术中控制眼内出血的有用辅助剂。
