de Bustros S, Glaser B M, Johnson M A
Arch Ophthalmol. 1985 Jun;103(6):837-9. doi: 10.1001/archopht.1985.01050060097034.
Intraocular bleeding is often a major problem during vitrectomy for proliferative diabetic retinopathy and trauma. We have studied the effect of thrombin on the control of intraocular bleeding during vitreous surgery in rabbit eyes. Thrombin (100 units/mL) infusion solution reduced the bleeding time by more than fivefold. Toxicity studies showed no adverse effect on the lens and corneal endothelium. Electroretinogram b-wave amplitudes were normal, but electroretinogram sensitivity was reduced by 0.5 log units in experimental eyes. Thrombin appears to be a potential agent for the control of intraocular bleeding during vitreous surgery.
眼内出血在增殖性糖尿病视网膜病变和外伤的玻璃体切除术中常常是一个主要问题。我们研究了凝血酶对兔眼玻璃体手术中眼内出血控制的影响。凝血酶（100单位/毫升）输注溶液使出血时间缩短了五倍多。毒性研究表明对晶状体和角膜内皮没有不良影响。视网膜电图b波振幅正常，但实验眼的视网膜电图敏感度降低了0.5对数单位。凝血酶似乎是玻璃体手术中控制眼内出血的一种潜在药物。
