炎症与癌症之间的新关联

A Novel Link between Inflammation and Cancer.

机构信息

Department of Microbiology & Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

出版信息

Cancer Cell. 2016 Dec 12;30(6):829-830. doi: 10.1016/j.ccell.2016.11.013.

DOI:10.1016/j.ccell.2016.11.013

PMID:27960080

Abstract

Immune checkpoint-blockade treatments targeting PD-1/PD-L1 have revolutionized cancer therapy. Hence, understanding the regulation of PD-L1 expression has major clinical relevance. In this issue of Cancer Cell, Lim et al. report that inflammation-induced and NF-κB-driven expression of deubiquitinating enzyme CSN5 leads to PD-L1 stabilization and immune suppression in tumors.

摘要

免疫检查点阻断治疗针对 PD-1/PD-L1，彻底改变了癌症治疗。因此，了解 PD-L1 表达的调控具有重要的临床意义。在本期《癌细胞》杂志上，Lim 等人报告称，炎症诱导和 NF-κB 驱动的去泛素化酶 CSN5 的表达导致肿瘤中 PD-L1 的稳定和免疫抑制。