Pratt M F, Bank H L, Schmehl M, Horton W D
Department of Otolaryngology and Communicative Sciences, Medical University, Charleston, SC.
Laryngoscope. 1989 Oct;99(10 Pt 1):1020-6. doi: 10.1288/00005537-198210000-00009.
Microvascular techniques offer important alternatives for reconstructive head and neck surgery. To test the viability of freeze-dried allografts, a pilot experimental study was performed using the rabbit model. Freeze-dried preserved arterial allografts were implanted into femoral artery defects in eight subjects. After 6 weeks, all grafts were harvested and prepared for histological and electron microscopic analysis. Immediate patency was 100%. One subject was excluded on the third postoperative day. Of the seven remaining grafts, three (43%) were patent at 6 weeks. These results are comparable to previous data obtained using freeze-dried arterial allografts in the same animal model. Although further investigation is required, this pilot study suggests possible future application of cryopreserved vascular micrografts.
微血管技术为头颈部重建手术提供了重要的替代方案。为了测试冻干同种异体移植物的生存能力，使用兔模型进行了一项初步实验研究。将冻干保存的动脉同种异体移植物植入八只实验对象的股动脉缺损处。6周后，取出所有移植物并准备进行组织学和电子显微镜分析。即时通畅率为100%。一名实验对象在术后第三天被排除。在其余七只移植物中，三只（43%）在6周时保持通畅。这些结果与之前在同一动物模型中使用冻干动脉同种异体移植物获得的数据相当。尽管需要进一步研究，但这项初步研究表明冷冻保存的血管微移植物未来可能有应用前景。
