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干扰素刺激基因因子与干扰素刺激反应元件之间相互作用的体内证据。

In vivo evidence of interaction between interferon-stimulated gene factors and the interferon-stimulated response element.

作者信息

Pine R, Darnell J E

机构信息

Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021.

出版信息

Mol Cell Biol. 1989 Aug;9(8):3533-7. doi: 10.1128/mcb.9.8.3533-3537.1989.

DOI:10.1128/mcb.9.8.3533-3537.1989
PMID:2796995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362401/
Abstract

Constitutive and interferon-inducible DNase hypersensitive sites in vivo are located in interferon-stimulated gene promoters near sequences that specifically bind constitutive or interferon-inducible proteins in vitro. Induced sites and proteins are transient or maintained, depending on cell type. Interferon-stimulated gene transcription is transient or maintained in parallel.

摘要

体内组成型和干扰素诱导型DNA酶超敏位点位于干扰素刺激基因启动子中，靠近在体外能特异性结合组成型或干扰素诱导型蛋白的序列。诱导的位点和蛋白是短暂的还是持续存在的，取决于细胞类型。干扰素刺激基因转录同样是短暂的或持续的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/362401/e9625be6950a/molcellb00056-0391-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/362401/b20a55cb27b2/molcellb00056-0390-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/362401/7de08926a4f7/molcellb00056-0391-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/362401/e9625be6950a/molcellb00056-0391-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/362401/b20a55cb27b2/molcellb00056-0390-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/362401/7de08926a4f7/molcellb00056-0391-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/362401/e9625be6950a/molcellb00056-0391-b.jpg

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引用本文的文献

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干扰素刺激基因因子2（ISGF2）的纯化与克隆：ISGF2（干扰素调节因子1）可与β干扰素基因和干扰素刺激基因的启动子结合，但并非二者的主要转录激活因子。
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