Leone Alessandro, Bedogni Giorgio, Ponissi Veronica, Battezzati Alberto, Beggio Valentina, Magni Paolo, Ruscica Massimiliano, Bertoli Simona
1Department of Food, Environmental and Nutritional Sciences (DeFENS),International Center for the Assessment of Nutritional Status (ICANS),University of Milan, Via Sandro Botticelli 21, 20133Milan,Italy.
2Department of Pharmacological and Biomolecular Sciences (DiSFeB),University of Milan,Via Balzaretti 9, 20133 Milan,Italy.
Br J Nutr. 2016 Dec;116(11):1984-1992. doi: 10.1017/S0007114516004141. Epub 2016 Dec 15.
The contribution of binge eating (BE) behaviour to cardiometabolic risk factors has been scarcely investigated so far. Previous studies have not considered the nutritional status and lifestyle of subjects suffering from BE. The aim of this study was to evaluate the contribution of BE to the metabolic syndrome (MS), its components, high total cholesterol and high LDL in a large sample of subjects, taking into account nutritional status, dietary habits, smoking status and physical activity. For this purpose, 5175 adults seeking a weight loss or maintenance programme were recruited. Anthropometrical measurements and blood parameters were measured. BE was evaluated using the Binge Eating Scale (BES). A fourteen-item questionnaire was used to evaluate the adherence to the Mediterranean diet. Smoking status and physical activity were investigated by interview. BE prevalence was 0·16 (95 % CI 0·15, 0·17). A sex- and age-adjusted Poisson regression model showed a higher prevalence of MS in binge eaters (0·33; 95 % CI 0·28, 0·37) compared with non-binge eaters (0·27; 95 % CI 0·25, 0·28, P=0·011). However, the statistical difference was lost after inclusion of BMI and lifestyle parameters in the multiple-adjusted model. We also evaluated the association between the continuous outcomes of interest and the BES score using a multivariable median regression model. We observed a positive, but clinically irrelevant, association between BES score and HDL levels (P<0·001). In conclusion, BE does not seem to be independently related to cardiometabolic risk factors. However, the screening and treatment of BE are of clinical relevance in order to reduce the risk of developing obesity.
到目前为止，暴饮暴食（BE）行为对心血管代谢危险因素的影响鲜有研究。以往的研究没有考虑到患有暴饮暴食症的受试者的营养状况和生活方式。本研究的目的是在大量受试者样本中，评估暴饮暴食对代谢综合征（MS）、其组成成分、高总胆固醇和高LDL的影响，同时考虑营养状况、饮食习惯、吸烟状况和身体活动情况。为此，招募了5175名寻求减肥或维持体重计划的成年人。测量了人体测量指标和血液参数。使用暴饮暴食量表（BES）评估暴饮暴食情况。使用一份包含14个条目的问卷评估对地中海饮食的依从性。通过访谈调查吸烟状况和身体活动情况。暴饮暴食的患病率为0·16（95%可信区间0·15, 0·17）。性别和年龄调整后的泊松回归模型显示，与非暴饮暴食者（0·27；95%可信区间0·25, 0·28，P = 0·011）相比，暴饮暴食者中MS的患病率更高（0·33；95%可信区间0·28, 0·37）。然而，在多变量调整模型中纳入BMI和生活方式参数后，统计学差异消失。我们还使用多变量中位数回归模型评估了感兴趣的连续结果与BES评分之间的关联。我们观察到BES评分与HDL水平之间存在正相关，但在临床上无显著意义（P < 0·001）。总之，暴饮暴食似乎与心血管代谢危险因素没有独立关联。然而，对暴饮暴食进行筛查和治疗对于降低肥胖发生风险具有临床意义。
