肺炎链球菌的持续基因适应性
The Ongoing Genetic Adaptation of Streptococcus pneumoniae.
作者信息
Richter Sandra S, Musher Daniel M
机构信息
Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA
Departments of Medicine and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA, and the Medical Care Line (Infectious Disease Section), Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
出版信息
J Clin Microbiol. 2017 Mar;55(3):681-685. doi: 10.1128/JCM.02283-16. Epub 2016 Dec 14.
Abstract
has demonstrated a remarkable ability to adapt during the conjugate vaccine era. The increasing incidence of serotype 35B disease and emergence of a multidrug-resistant clone reported in this issue of the (L. Olarte et al., J Clin Microbiol 55:724-734, 2017, https://doi.org/10.1128/JCM.01778-16) underscore the limitations of pneumococcal vaccines that target the polysaccharide capsule.
摘要
在结合疫苗时代已显示出显著的适应能力。本期《临床微生物学杂志》（L. Olarte等人，《临床微生物学杂志》55:724 - 734，2017年，https://doi.org/10.1128/JCM.01778 - 16）报道的35B血清型疾病发病率上升以及多重耐药克隆的出现，突显了针对多糖荚膜的肺炎球菌疫苗的局限性。
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