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Vaccine. 2016 Jun 3;34(26):2959-2961. doi: 10.1016/j.vaccine.2016.03.107. Epub 2016 Apr 12.
3
A Review of Pneumococcal Vaccines: Current Polysaccharide Vaccine Recommendations and Future Protein Antigens.肺炎球菌疫苗综述：当前多糖疫苗推荐及未来蛋白质抗原
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Clin Infect Dis. 2016 May 1;62(9):1119-25. doi: 10.1093/cid/ciw067. Epub 2016 Feb 7.
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Carriage burden, multiple colonization and antibiotic pressure promote emergence of resistant vaccine escape pneumococci.携带负担、多重定植和抗生素压力促使耐药性肺炎球菌疫苗逃逸株的出现。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 5;370(1670):20140342. doi: 10.1098/rstb.2014.0342.
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Bacterial load of pneumococcal serotypes correlates with their prevalence and multiple serotypes is associated with acute respiratory infections among children less than 5 years of age.肺炎球菌血清型的细菌载量与其流行率相关，并且多种血清型与5岁以下儿童的急性呼吸道感染有关。
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Changes in pneumococcal serotypes and antimicrobial resistance after introduction of the 13-valent conjugate vaccine in the United States.美国引入13价结合疫苗后肺炎球菌血清型及抗菌药物耐药性的变化
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肺炎链球菌的持续基因适应性

The Ongoing Genetic Adaptation of Streptococcus pneumoniae.

作者信息

Richter Sandra S, Musher Daniel M

机构信息

Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA

Departments of Medicine and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA, and the Medical Care Line (Infectious Disease Section), Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.

出版信息

J Clin Microbiol. 2017 Mar;55(3):681-685. doi: 10.1128/JCM.02283-16. Epub 2016 Dec 14.

DOI:10.1128/JCM.02283-16
PMID:27974545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5328434/
Abstract

has demonstrated a remarkable ability to adapt during the conjugate vaccine era. The increasing incidence of serotype 35B disease and emergence of a multidrug-resistant clone reported in this issue of the (L. Olarte et al., J Clin Microbiol 55:724-734, 2017, https://doi.org/10.1128/JCM.01778-16) underscore the limitations of pneumococcal vaccines that target the polysaccharide capsule.

摘要

在结合疫苗时代已显示出显著的适应能力。本期《临床微生物学杂志》（L. Olarte等人，《临床微生物学杂志》55:724 - 734，2017年，https://doi.org/10.1128/JCM.01778 - 16）报道的35B血清型疾病发病率上升以及多重耐药克隆的出现，突显了针对多糖荚膜的肺炎球菌疫苗的局限性。