Bădescu S V, Tătaru C P, Kobylinska L, Georgescu E L, Zahiu D M, Zăgrean A M, Zăgrean L
Department of Physiology and Fundamental Neuroscience, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; Emergency Eye Hospital, Bucharest, Romania.
J Med Life. 2016 Jul-Sep;9(3):275-279.
Diabetes mellitus modifies the expression of adenosine receptors in the brain. Caffeine acts as an antagonist of A1 and A2A adenosine receptors and was shown to have a dose-dependent biphasic effect on locomotion in mice. The present study investigated the link between diabetes and locomotor activity in an animal model of streptozotocin-induced diabetes, and the effects of a low-medium dose of caffeine in this relation. The locomotor activity was investigated by using Open Field Test at 6 weeks after diabetes induction and after 2 more weeks of chronic caffeine administration. Diabetes decreased locomotor activity (total distance moved and mobility time). Chronic caffeine exposure impaired the locomotor activity in control rats, but not in diabetic rats. Our data suggested that the medium doses of caffeine might block the A2A receptors, shown to have an increased density in the brain of diabetic rats, and improve or at least maintain the locomotor activity, offering a neuroprotective support in diabetic rats. : STZ = streptozotocin, OFT = Open Field Test.
糖尿病会改变大脑中腺苷受体的表达。咖啡因作为A1和A2A腺苷受体的拮抗剂，已被证明对小鼠的运动有剂量依赖性的双相作用。本研究在链脲佐菌素诱导的糖尿病动物模型中，研究了糖尿病与运动活动之间的联系，以及低中剂量咖啡因在此方面的作用。在糖尿病诱导6周后以及再进行2周慢性咖啡因给药后，通过旷场试验研究运动活动。糖尿病会降低运动活动（移动的总距离和活动时间）。慢性咖啡因暴露会损害对照大鼠的运动活动，但对糖尿病大鼠没有影响。我们的数据表明，中等剂量的咖啡因可能会阻断A2A受体，该受体在糖尿病大鼠大脑中的密度增加，并改善或至少维持运动活动，为糖尿病大鼠提供神经保护支持。：STZ = 链脲佐菌素，OFT = 旷场试验
